目的 研究华山参（漏斗泡囊草Physochlaina infundibularis干燥根）的化学成分。方法 采用正相硅胶、Sephadex LH-20、HPLC等色谱手段，对华山参药材进行分离纯化，并利用质谱、核磁共振等方法进行化合物结构鉴定。结果 从华山参正丁醇部位初步分离得到3个酰胺类化合物，分别鉴定为N-甲酰基-N-阿魏酰基-1，4-丁二胺（1）、N-乙酰基-N-顺式阿魏酰基-1，4-丁二胺（2）、N-乙酰基-N-阿魏酰基-1，4-丁二胺（3）。结论 化合物1、2为新化合物，分别命名为华山参丁二胺A、华山参丁二胺B；化合物3为首次从泡囊草属植物中分离得到。

Objective To study the chemical constituents of Physochlaina infundibularis. Methods The chemical constituents were isolated by chromatography with silica gel, HPLC, Sephadex LH-20. The structures were identified by MS and NMR analyses. Results Three amides were separated from P. infundibularis and elucidated as trans N-formyl-N-feruloyl-putrescine (1), cis N-acetyl-N-feruloyl-putrescine (2) and trans N-acetyl-N-feruloyl-putrescine (3). Conclusion Compounds 1 and 2 are new compounds, and compound 3 is separated from the genus Physochlaina for the first time.

国家重点研发计划-战略性国际科技创新合作专项（2020YFE0201800）；河南省科技攻关项目（202102310183，202102310173）；河南省中医药科学研究专项课题-重大项目（2018ZYZD12）