补骨脂素是源于补骨脂Psoralea corylifolia的香豆素成分，具有抗骨质疏松、神经保护、抗肿瘤、雌激素样、抗炎等多重药理作用，有着良好的临床应用潜力。随着对补骨脂用药安全问题的不断关注，近年来关于补骨脂素的肝脏毒性研究也逐渐增多。通过查阅近20年国内外相关文献，对补骨脂素的药理作用和肝毒性研究概况进行整理和总结，为补骨脂素的进一步研究和临床应用提供参考。

Psoralen is a coumarin component derived from Psoralea corylifolia. It has multiple pharmacological effects, such as anti-osteoporosis, neuroprotective, anti-tumor, estrogen-like, and anti-inflammatory, which has a good application potential in clinic. With the increasing attention paid to the safety of psoralen, studies on liver toxicity caused by psoralen have been gradually increasing in recent years. The pharmacological effects and hepatotoxicity of psoralen in the past 20 years were reviewed in this paper, in order to provide reference for the further research and clinical application of psoralen.

R282.71

国家新药创制重大专项（2016ZX09101073）；军队后勤重点项目（BKJ15J005）