环肽是植物来源的超稳定肽，是由头至尾环化骨架和形成胱氨酸结的3个二硫键组成的非常稳定的化合物。与其他类似肽相比，环肽的这种独特的拓扑化学结构使它们对化学、热和生物降解异常稳定，超强的稳定性可使它们在医药学领域方面取得很多进展。植物环肽是植物研究的一个新领域，由于其具有多种生物活性，引起了很多科学研究工作者的广泛重视与探究。多肽类药物的低稳定性与低的传递效率阻碍了其发展，而植物环肽的存在为多肽类药物存在问题的解决提供新的途径。综述了植物环肽的药理活性及其作用机制，为植物环肽发展成为药物应用于临床提供理论基础。

Cyclotide is a plant-derived remarkable-stable peptide, which consists of a head-to-tail cyclization skeleton and a cyclic cysteine knot formed by three disulfide bonds. Compared with other similar peptides, the unique topological chemical structure of cyclotides makes them extremely stable to chemical, thermal and biological degradation, and their super-strong stability make them become attractive subject in the field of medicine and pharmacy. Cyclotides in plants are a new field of plant research. Because of their various biological activities, they have attracted extensive attention and exploration from many scientific researchers. The low stability and low delivery efficiency of polypeptide drugs hinder their development, while the existence of cyclotides in plants provides a new way to solve the existing problems of polypeptide drugs. The pharmacological activities and mechanisms of cyclotides in plants are summarized in this paper, which provides theoretical basis for the development of cyclotides in plants into drugs for clinical application.

R284.194

国家自然科学基金资助项目（31570506）；广东药科大学创新强校项目（2017KCXTD020）