骨质疏松是一种全身骨骼疾病，对患者及社会均产生巨大的医疗负担。药物治疗是抗骨质疏松的主要干预措施，但客观存在的不良反应降低了患者的服用依从性从而影响用药效果。中医药防治骨质疏松具有较好的疗效以及安全性，但其作用机制需深入研究。通路调控骨质疏松的进展，是进行骨质疏松病理机制和药理学研究的主要靶点之一。近几年，针对中药有效成分对骨质疏松信号通路的调控机制作了大量研究。综述近年来有关中药有效成分干预生物学信号通路的相关研究成果，为抗骨质疏松症的新药开发、基础研究以及临床应用提供思路。

Osteoporosis is a systemic skeletal disease that causes a huge medical burden on patients and society. Drug treatment is the main intervention for anti-osteoporosis, but objectively existing adverse reactions reduce the patient's compliance and affect the effect of medication. Traditional Chinese medicine has good curative effect and safety in the prevention and treatment of osteoporosis, but its mechanism of action needs to be further studied. The pathway regulates the progress of osteoporosis and is one of the main targets for osteoporosis pathological mechanism and pharmacological research. In recent years, an increasing number of studies have been made on the regulatory mechanism of osteoporosis signaling pathways by active ingredients of Chinese materia medica. Recent research results on the active components of Chinese materia medica interfering with biological signaling pathways was reviewed in this article, in order to provide ideas for new drug development, basic research, and clinical applications for osteoporosis.

R285

国家自然科学基金资助项目（82004383）；国家自然科学基金资助项目（81974574）；国家自然科学基金资助项目（81473698）；广东省财政厅资助项目（[2014]157，[2018]8号）；广东省中医院中医药科学技术研究专项（YN2019ML08，YK2013B2N19，YN2015MS15）；中国博士后科学基金资助项目（2018M633036）；广东省医学科学技术研究基金项目（B2019091，A2017215）；广东省中医药管理局项目（20201129，20164020，20181119）；教育部高等学校博士点科研基金项目（20124425110004）；广东省科技计划项目（2020A1414050050）；广东省普通高校重点科研平台和科研项目（2018KQNCX041）