目的 对白芍进行化学成分研究。方法 综合应用多种现代色谱分离技术进行系统的分离和纯化，根据化合物的理化性质和核磁共振波谱数据进行结构鉴定。结果 从白芍65%乙醇提取物中分离得到11个化合物，分别鉴定为（4S）-紫苏酸α-L-阿拉伯糖基-（1'→6''）-β-D-葡萄糖苷（1）、4，9-二羟基-8，10-去氢百里香酚-1-O-β-D-葡萄糖苷（2）、大黄素-8-O-β-D-葡萄糖苷（3）、白藜芦醇（4）、苯甲酸葡萄糖苷（5）、猫儿刺酚苷A（6）、儿茶素（7）、没食子酸甲酯（8）、没食子酸乙酯（9）、3-甲氧基没食子酸（10）、1，2，3，4，6-O-五没食子酰葡萄糖苷（11）。结论 化合物1为新化合物，命名为紫苏酸苷；化合物2和5为首次从芍药属植物中分离得到。

Objective To study the constituents from the roots of Paeonia lactiflora. Methods The chemical constituents were isolated by various chromatographic techniques and their structures were elucidated by physicochemical properties and NMR data. Results Eleven compounds were obtained and characterized as (4S)-perillic acid 6-O-α-L-arabinopyranosyl-(1'→6'')- β-D-glucopyranosyl (1), 4,9-dihydroxy-8,10-dehydrothymol-1-O-β-D-glucoside (2), emodin-8-O-β-D-glucoside (3), resveratrol (4), β-D-glucopyranosyl benzoate (5), ilexperphenoside A (6), catechol (7), methyl gallate (8), ethyl gallate (9), 3-methoxygallic acid (10), 1,2,3,4,6-penta-O-galloyl-β-D-glucopyranoside (11). Conclusion Compound 1 is identified as a new compound, named perillic acid glycoside, compounds 2 and 5 are identified from the genus Paeonia for the first time.

R284.1

江苏省中医药局科技项目（YB2017068）