基于中医药理论现代化研究的现状和发展趋势，结合当前亟需解决的3项重大前沿科学问题和3项重大工程技术难题，辨中医药现代化问题之症结，明中医药现代化难题破解之必由途径，阐述中医药超分子“气析”理论对其破解的决定性作用。置人体与中药于自然界生物演化的历史长河之中，运用超分子化学解析生命进化轨迹，溯中医药理论产生之源。在漫长的生物进化过程中，自然界的各类分子遵循超分子化学规律，按“印迹模板”逐级形成超分子体，由简单到复杂，由无生命的无机络合物再到有生命的酶系统，由简单的单分子到复杂的超分子机器，无不打上超分子化学的烙印。在由逐级超分子体构成生物体链条中，生物超分子化学作用贯穿始终。由“印迹模板”通道结构逐级有序排列构成经络，管控“社会分子”；在人体心脏搏血的推动下，溶于血液中的客体小分子物质在脏腑经络主体大分子的“印迹模板”通道中按“气析”进行迁移，宏观表现出中医所述经络脏腑对小分子作用的各向异性，亦即脏象。据此可阐明生命科学本原和中医药“理”“法”“方”“药”原创性理论，解决中医药重大科学问题和工程技术难题，重构并融合中医药基础理论，最终实现现代化。

Based on the current situation and development trend of the modernization of traditional Chinese medicine (TCM) theory, combined with three major frontier scientific problems and three major engineering and technical problems needed to be solved, the crux of the modernization problem of TCM was identified, the way to solve the modernization problem of TCM was put forward, and the decisive role of supramolecular "qi chromatography" theory of TCM in cracking these problems was elaborated. The human body and Chinese materia medica are observed clearly in the long history of biological evolution in nature, while supramolecular chemistry has played an important role in analyzing the evolutionary trajectory of life and tracing the origin of TCM theory. In the long process of biological evolution in nature, all kinds of molecules in nature follow supramolecular chemistry, forming supramolecular bodies according to "imprinted template" step by step, from simple to complex, from inanimate inorganic complexes to living enzyme systems, from single simple molecules to complex supramolecular machines, through which the interaction of the biological molecules runs in the chain of organisms composed of supramolecular bodies. Meridians, which are the result of the orderly arrangement of the "imprinted template" channel structure step by step, are the basic form to control molecules. Under the impetus of human heart beating, the small molecules substances dissolved in blood migrate into and act on according to the "imprinting template" embed in main macromolecule of meridians and viscera. It shows the anisotropy of the action of meridians and viscera on small molecules, that is visceral phenomena, on which the essential of life science and the original theory of "principle", "method", "prescription" and "medicine" for TCM will be clarified. Major scientific and engineering problems of TCM will be solved on the basis of supramolecular chemistry, and the basic theory of TCM will be reconstructed and modernized into a union with contemporary medicine.

R285.1

国家自然科学基金资助项目（81573691，81874507）；湖南省教育厅创新平台开放基金项目（18K071）；长沙市科技计划项目（kq1907137）