淫羊藿素是淫羊藿Epimedii Folium所含的活性成分之一，近年来研究表明淫羊藿素具有抗肿瘤、神经保护、心血管保护、免疫调节、骨保护等多种作用，但因其水溶性差、口服吸收差、生物利用度低等缺点，限制了其临床应用。利用新型给药系统可大幅提高淫羊藿素的溶解度、口服吸收和生物利用度，具有良好的应用前景。基于近年来的淫羊藿素研究进展，对淫羊藿素的药理作用和新型给药系统进行了综述，旨在为淫羊藿素的临床应用与新药研发提供依据。

Icaritin is one of the major bioactive compounds of Epimedii Folium. In recent years, scientific and pharmacological studies have shown that icaritin possesses broad therapeutic effects, especially in anti-tumor, enhancing osteoprotective, cardioprotective, neuro-protective function. However, its clinical application was limited by poor water solubility, poor oral absorption and low bioavailability. New drug delivery system has great application prospect in improving solubility of icaritin, oral absorption and bioavailability. Therefore, the current review paper aims to summarize the pharmacological effects of icaritin and briefly introduce some new drug delivery of icaritin, to provide theoretical basis for its clinical application and new drug development. Key words: icaritin; pharmacology effects; new drug delivery system; antitumor; research progress

R285;R283.6

国家自然科学基金资助项目（81873016）；国家自然科学基金青年项目（81703714）