中药是中华民族的瑰宝，在人类与疾病作斗争的进程中发挥了不可磨灭的功绩。在建设健康中国的时代背景下，如何使中药在防病和治病中发挥独特优势是现今关注的焦点。中药具有"多组分、多效用、多靶点、整体调节"作用特点，仅从"局部观"研究中药不足以揭示其内在本质，故"整体观"的研究思路势在必行。系统生物学是从整体视角认识生物体的研究技术，与中药"整体观"研究思路不谋而合，故基于系统生物学的中药研究策略具有高度可行性。综述了系统生物学的主要技术基因组学、转录组学、蛋白组学、代谢组学、微生物组学、多组学联合以及网络药理学技术在中药成分、药理和毒理、基源鉴别、栽培与遗传育种方面研究中的应用概况，以期为基于"整体观"思路的系统生物学研究策略在中药中进一步应用提供参考。

Traditional Chinese medicine is the treasure of China, which has played an indelible role in the process of fighting against diseases. Under the background of times of building Healthy China, how to play the unique advantages of traditional Chinese medicine in the disease prevention and treatment is the focus of attention. Traditional Chinese medicine has the characteristics of "multi-component, multi-target, and overall regulation", and it's not enough to reveal its internal essence only by the way of "local concept", so the research thinking of "overall concept"is imperative. System biology, a research technology, which understands the organism from a holistic perspective and coincides with the way of "overall concept"of traditional Chinese medicine. Therefore, the research strategy of traditional Chinese medicine based on system biology with highly feasible. In this paper, the application of system biology technologies, such as genomics, transcriptome, proteomics, metabonomics, microbiomics, omics combination and network pharmacology technology, in the research of ingredients, pharmacology and toxicology, identification, cultivation and genetic breeding of traditional Chinese medicine was reviewed, in order to provide reference for the further application of system biology strategy in the research of traditional Chinese medicine, based on the idea of "overall concept".

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吉林省科技发展计划项目（20200404023YY）；长春科技学院科研启动基金项目（CCKJ201711）