纳米制剂虽可改善药物理化性质，但其易被单核吞噬细胞识别和清除，不仅会降低药物体内半衰期，也易引起免疫原反应，影响药物安全有效使用。而将细胞膜与新型纳米技术结合后，在增加细胞相容性的同时，又可保留纳米制剂的优点，进一步增强靶器官或组织的靶向性，提高疗效。目前，脑屏障的存在限制了所有大分子物质和98%小分子药物进入脑部，成为脑病治疗面临的主要问题。巨噬细胞是常见的免疫细胞，在脑部疾病的发展与预后中发挥重要作用。因此，将巨噬细胞膜与纳米制剂结合，使其成为免疫系统自身物质后避免被识别和清除，增加药物体内循环量；再利用巨噬细胞的血脑屏障透过性，增加药物脑部含量，提高药物临床疗效。中药成分复杂，疗效显著，但大部分存在溶解性差、稳定性差等问题，导致给药后体内生物利用度低，影响应用。基于国内外文献，整合巨噬细胞膜仿生纳米制剂在脑部疾病中的应用及其对中药活性成分成药性的作用，以期促进中药资源开发与利用。

Although nano preparations could improve the physicochemical properties of drugs, they are easy to be recognized and cleared by mononuclear phagocytes, which will not only reduce the half-life of drugs, but also cause immunogen reaction, thus affecting the safe and effective use of drugs. The combination of cell membrane and new nanotechnology will increase the cell compatibility with the advantages of nano preparations, further enhance the targeting effect of target organs or tissues, and improve the efficacy. At present, the existence of the brain barrier restricts the entry of all macromolecular substances and 98% small molecule drugs into the brain, becoming the main problem in the treatment of encephalopathy. Macrophages are common immune cells and play an important role in the development and prognosis of brain diseases. Therefore, the combination of macrophage membranes and nano preparations becomes the immune system's own substances to avoid recognition and clearance, and increase the circulation of drugs, then reuse the blood-brain barrier permeability of macrophages to increase the drug into brains to improve the clinical efficacy. Traditional Chinese medicine has complex components and significant curative effect, but most of them have problems in poor solubility and stability, which lead to low bioavailability in vivo and affect the application. Therefore, based on domestic and foreign literatures, this article integrates the application of macrophage membrane modified nano-preparations in encephalopathy and its effects on the medicinal properties of active ingredients of traditional Chinese medicine, in order to promote the development and utilization of traditional Chinese medicine resources.

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国家自然科学基金资助项目（81673615）；四川省中医药管理局项目（2018QN009）；成都中医药大学校级科研基金资助项目（QNXZ2018018）；全国中药特色技术传承人才培训项目（T20194828003）