目的 探讨10种重楼药材中7种有效成分含量，并进行化学成分整合评控，为其资源评价提供了科学依据。方法 收集不同产地55批重楼药材，采用UPLC法测定重楼皂苷I、重楼皂苷Ⅱ、重楼皂苷VI、重楼皂苷VⅡ、薯蓣皂苷、重楼皂苷H、纤细薯蓣皂苷的含量，进一步采用TOPSIS数学模型对含量结果进行归一化与多指标数据集成化，获得重楼中7种指标的化学品质综合指数。结果 10种重楼药材的综合评价排名由高到低依次为长柱重楼（C_i=0.275 5） > 多叶重楼（C_i=0.273 2） > 大理重楼（C_i=0.269 8） > 滇重楼（C_i=0.244 5） > 南重楼（C_i=0.234 5） > 狭叶重楼（C_i=0.159 1） > 黑籽重楼（C_i=0.141 6） > 矮重楼（C_i=0.117 8） > 七叶一枝花（C_i=0.115 1） > 毛重楼（C_i=0.114 9），表明不同种重楼化学综合质量差异较大，其长柱重楼、多叶重楼和大理重楼的化学综合质量优于滇重楼，南重楼与滇重楼的结果较为接近，可作为滇重楼资源扩充的优势品种。结论 通过TOPSIS整合评控对重楼类中药材的质量评价有一定的参考依据。

Objective To explore the content of seven active compounds in 10 kinds of medicinal herbs of Paridis Rhizoma, and to carry out chemical composition integration evaluation, which provides a scientific basis for its resource utilization. Methods A total of 55 batches of medicinal herbs were collected from different areas, and their saponins I, saponins Ⅱ, saponins VI, saponins VⅡ, diosgenin, saponins H, and saponins were determined by ultra performance liquid chromatography. Then, TOPSIS model was used to normalize the content results and integrate the multi-indicator data to obtain a comprehensive index of content of seven active compounds. Results The 10 kinds of medicinal herbs of Paridis Rhizoma were ranked from long to low was Paris forrestii (C_i=0.275 5) > Paris polyphylla (C_i=0.273 2) > Paris daliensis (C_i=0.269 8) > Paris polyphylla var. yunnanensis (C_i=0.244 5) > Paris vietnamensis (C_i=0.234 5) > Paris polyphylla var. stenophylla (C_i=0.159 1) > Paris thibetica (C_i=0.141 6) > Paris polyphylla var. nana (C_i=0.117 8) > P. vietnamensis (C_i=0.115 1) > Paris mairei (C_i=0.114 9), indicating that comprehensive quality of 10 kinds of medicinal herbs of Paridis Rhizoma had a large gap. The overall quality of P. forrestii, P. polyphylla and P. daliensis are better than that of P. polyphylla var. yunnanensis, and the comprehensive evaluation results of P. vietnamensis and P. polyphylla var. yunnanensis are closer that can be used as an alternative species for resource mining. Conclusion The comprehensive evaluation of chemical quality has certain reference value for the quality evaluation of Paridis Rhizoma

R286.2

国家自然科学基金资助项目（31860080）；云南省地方本科高校（部分）基础研究联合专项（2017FH-001-097）；大理州重点科技支撑专项计划（D2018SA01）；大理大学中药资源与民族药创新团队（ZKLX2019318）