目的 采用数据挖掘技术总结中医药治疗高同型半胱氨酸血症的用药规律。方法 收集中国知网、维普中文期刊服务平台、万方数据库、中国生物医学文献服务系统建库至2019年12月31日发表的中医治疗高同型半胱氨酸血症的相关文献，采用中医传承辅助平台（TCMISS V 2.5）统计用药频次、常用药对及药物组合，采用关联规则、改进的互信息法、复杂系统熵聚类分析对药物关联规则及核心药物组合进行分析，采用无监督的熵层次聚类进行新处方分析。结果 共筛选出符合条件的方剂156首，涉及中药199味，使用频次≥10的中药有川芎、茯苓、丹参、天麻、黄芪等46味，主要是活血化瘀药、利水渗湿药、平肝熄风药及补虚药；挖掘共得到高频药物组合33个，出现频次前5位的组合是茯苓-天麻、川芎-当归、川芎-黄芪、红花-川芎及川芎-天麻；演化共得到核心药物组合20组，潜在新处方10个。结论 中医药治疗高同型半胱氨酸血症多使用活血化瘀药、利水渗湿药、平肝熄风药、化痰止咳平喘药及补虚药，组方显示了以化痰降浊、活血化瘀为主，兼以益气健脾、利水渗湿、祛痰宽胸的治法，体现了标本兼治的中医特色。

Objective To summarize the medication rules of traditional Chinese medicine for treatment of hyperhomocysteinemia (HHcy) by data mining. Methods To collect the relevant literatures of TCM treatment of HHcy from CNKI, VIP, Wanfang Data, CBM from the establishment of the database to December 31, 2019. TCMSS V 2.5 was used to count the frequency of medication, common drug pairs and drug combinations; Association rules, improved mutual information method, complex system entropy cluster analysis were used to analyze drug association rules and core drug combinations; Unsupervised entropy hierarchical clustering was used to analyze the new prescriptions. Results There were 156 prescriptions with 199 Chinese medicinal herbs and 46 Chinese medicinal herbs of them with functions of promoting blood circulation and removing blood stasis, promoting urination and draining dampness, pacifying liver and extingushing wind and tonic deficiency were used for more than 10 times,. A total of 33 high-frequency drug combinations were obtained through data mining, and the top five combinations were Poria-Gastrodiae Rhizoma, Chuanxiong Rhizoma-Angelicae Sinensis Radix, Chuanxiong Rhizoma-Astragali Radix, Carthami Flos-Chuanxiong Rhizoma and Chuanxiong Rhizoma-Gastrodiae Rhizoma. A total of 20 core drug combinations and 10 potential new prescriptions were obtained through evolution. Conclusion In the treatment of HHcy in TCM, blood-activating and stasis-resolving medicines, urination-promoting and dampness-draining medicines, liver-pacifying and wind-extingushing medicines and tonic deficiency medicines were mostly used. These prescriptions show that the main methods of promoting blood circulation and removing blood stasis, and resolving phlegm and turbidity, as well as supplementing qi and invigorating spleen, promoting urination and draining dampness, removing phlegm and widening chest reflect the characteristics of addressing both the symptoms and root causes of TCM.

R28

甘肃省中医药管理局科研项目（GZK-2019-41）；甘肃省人民医院研发攻关项目（18GSSY2-3）