目的 通过对《中华人民共和国卫生部药品标准——中药成方制剂》（《中药部颁标准》）含延胡索-川楝子药对（简称“延胡索-川楝子”）方剂组方规律的研究，以期为临床应用及方剂的后续产品开发提供理论依据。方法 收集整理《中华人民共和国卫生部药品标准——中药成方制剂》中包含延胡索-川楝子的方剂，录入中医传承辅助平台软件（V.2.5）建立数据库，统计主治病症频次、配伍药材频次、组方归经频次；采用关联规则Apriori算法对含延胡索-川楝子方剂的药材核心组合进行统计分析（设置支持度分别为10%、20%、30%，置信度为0.90）；选择较高频次归经进行组方规律分析。结果 共筛选出51首含延胡索-川楝子方剂，涉及主治疾病8种（频次≥2），包括胃痛、胁痛、带下病、痛经、盆腔炎、月经失调等；涉及主治证候9种（频次≥2），包括肝胃不和证、气滞血瘀证、肝郁气滞证、肝郁血虚证、胞宫血热证等；常配伍药材17味（频次≥5），包括白芍、木香、甘草、香附等；常用药材组合20种（频次≥6），其中核心药材组合包括延胡索-白芍-川楝子、延胡索-甘草-川楝子、延胡索-木香-川楝子、延胡索-香附-川楝子；组方归肝脾胃经频次较高；常与延胡索-川楝子配伍归肝经的组方核心药材有5种，包括木香、白芍、陈皮、砂仁、沉香，其中核心药材组合（频次≥7）包括延胡索-木香-川楝子、延胡索-白芍-川楝子、延胡索-陈皮-川楝子、延胡索-陈皮-白芍-木香-川楝子。常与延胡索-川楝子配伍归脾胃经的组方核心药材有3种，包括沉香、白芍、砂仁，其中核心药材组合（频次≥4）包括延胡索-沉香-川楝子、延胡索-白芍-川楝子、延胡索-砂仁-川楝子。结论 《中华人民共和国卫生部药品标准——中药成方制剂》中含延胡索-川楝子方剂所用药物多理气止痛之功效，用药较为集中，组方法度清晰。此外，以3种归经组方规律的对比分析，反映了含延胡索-川楝子方剂不同归经组方的用药规律和配伍特点，为“异病同治”提供理论支持，也为延胡索-川楝子药对更好的应用于临床提供理论支持。

Objective To explore the combination rule of Corydalis Rhizoma-Toosendan Fructus drug pair through the research in "Pharmaceutical Standard of the Ministry of Health of the People's Republic of China-Traditional Chinese Medicine Formulation", so as to provide theoretical basis for clinical application and new product development of this pair. Methods The prescriptions containing Corydalis Rhizoma-Toosendan Fructus were collected from Pharmaceutical Standard of Ministry of Public Health of the People's Republic of China-TCM Formulation and input into TCM inheritance support platform software (V2.5) to establish the database. The frequency of attending diseases, compatibility medicinal materials, and meridian of drug were analyzed statistically. The core combination of medicinal materials in the prescriptions containing Corydalis Rhizoma-Toosendan Fructus were analyzed statistically with association rule Apriori algorithm (support degrees were 10%, 20%, 30%, confidence was 0.90). Meridian of drug with higher compatibility frequency were selected and analyzed in respect of prescription rules. Results A total of 51 prescriptions containing Corydalis Rhizoma-Toosendan Fructus were screened, eight kinds of attending diseases (frequency ≥ 2), such as stomachache, hypochondriac pain, leukorrhagia, dysmenorrhea, pelvic inflammation, menstrual disorder, etc. Nine kinds of attending syndrome (frequency ≥ 2) were included such as liver-stomach disharmony, syndrome of qi stagnation and blood stasis, syndrome of liver depression and qi stagnation, syndrome of liver depression and blood deficiency, syndrome of blood-heat in uterus, etc. There were 17 commonly used compatibility medicinal materials (frequency ≥ 5), including Paeoniae Radix Alba, Aucklandiae Radix, Glycyrrhizae Radix et Rhizoma, Cyperi Rhizoma etc. There were 20 commonly used medicinal materials combinations (frequency ≥ 6), including Corydalis Rhizoma-Paeoniae Radix Alba-Toosendan Fructus, Corydalis Rhizoma-Aucklandiae Radix-Toosendan Fructus, Corydalis Rhizoma-Glycyrrhizae Radix et Rhizoma-Toosendan Fructus, Corydalis Rhizoma-Cyperi Rhizoma-Toosendan Fructus. Meridian of drug with higher compatibility frequency was distributed to liver, spleen and stomach channel tropism. There were five kinds of core medicinal materials commonly acted on the liver meridian with Corydalis Rhizoma-Toosendan Fructus, including Aucklandiae Radix, Paeoniae Radix Alba, Citri Reticulatae Pericarpium, Amomi Fructus, and Aquilariae Lignum Resinatum. There were commonly used core medicinal materials combinations (frequency ≥ 7), including Corydalis Rhizoma-Aucklandiae Radix-Toosendan Fructus, Corydalis Rhizoma-Paeoniae Radix Alba-Toosendan Fructus, Corydalis Rhizoma-Citri Reticulatae Pericarpium-Toosendan Fructus, Corydalis Rhizoma-Citri Reticulatae Pericarpium-Paeoniae Radix Alba-Aucklandiae Radix-Toosendan Fructus. There were three kinds of core medicinal materials commonly acted on the spleen meridian and the stomach meridian with Corydalis Rhizoma-Toosendan Fructus, including Aquilariae Lignum Resinatum, Aucklandiae Radix and Amomi Fructus. There were commonly used core medicinal materials combinations (frequency ≥ 4), including Corydalis Rhizoma-Aquilariae Lignum Resinatum-Toosendan Fructus, Corydalis Rhizoma-Aucklandiae Radix-Toosendan Fructus, Corydalis Rhizoma-Amomi Fructus-Toosendan Fructus. Conclusions Herbal medicines used frequently in prescriptions containing Corydalis Rhizoma-Toosendan Fructus can regulate qi flowing for relieving pain. The medicine using is relatively concentrated, and the composition is clear. In addition, Prescription rules of three kinds of meridian prescriptions were chosen to make comparative analysis, and the compatibility features of the prescriptions containing Corydalis Rhizoma-Toosendan Fructus was reflected in different meridian of drug and the composing principles. This study also can provide theoretical basis for treating different diseases with same method and the better application of Corydalis Rhizoma-Toosendan Fructus in clinical practice.

R28

浙江中医药大学校级科研基金（2019ZR16）；浙江中医药大学时珍青年人才培养计划资助项目（SZZ201813）