目的 研究圆齿野鸦椿Euscaphis konishii的化学成分。方法 采用硅胶柱色谱，凝胶柱色谱、制备高效液相色谱等分离技术进行分离纯化，利用现代波谱学手段进行化合物结构鉴定。结果 从圆齿野鸦椿95%乙醇提取物的醋酸乙酯部位中分离得到8个化合物，分别鉴定为4（R）-（4'-羟基苯甲酰）二氢呋喃-2（3H）-酮（1）、6-hydroxymellein（2）、euscapholide（3）、去氢催吐萝芙木醇（4）、没食子酸乙酯（5）、tetraketide（6）、对羟基苯甲酸（7）、烟碱酸（8）。结论 化合物1为新化合物，命名为圆齿野鸦椿内酯；除化合物3和6外，其余均为首次从该属植物中分离得到。

Objective To study the chemical constituents of Euscaphis konishii. Methods The chemical constituents from 95% EtOH extract of the stems of E. konishii were isolated by repeated chromatograph with silica gel, Sephadex LH-20 and semi-preparative RP-HPLC. The structure of the separated chemical components was identified by modern spectroscopy identification. Results Eight compounds were isolated from the ethyl acetate fraction of 95% EtOH extract of E. konishii, and identified as 4 (R)-(4'-hydroxybenzoyl) dihydrofuran-2(3H)-one (1), 6-hydroxymellein (2), euscapholide (3), dehydrovomifoliol (4), ethyl gallate (5), tetraketide (6), p-hydroxybenzoic acid (7) and nicotinic acid (8). Conclusion Except for compounds 3 and 6, they are all isolated for the first time in this genus, and all compounds are isolated for the first time in this plant. Among them, compound 1 is a new compound named konieuscaphide.

R284.1

国家自然科学基金资助项目（31700292）