目的 通过数据挖掘的方法探究首批国医大师治疗脑卒中急性期的处方用药规律。方法 检索并整理国医大师经验书籍、公开发表的期刊文献、古今医案云平台V1.5中的国家级名中医工作室共享医案，筛选首批国医大师治疗脑卒中急性期的医案数据，建立标准化医案数据库，规范化药名后采用系统集成的统计分析、关联规则分析、复杂网络等方法，分析医案的组方用药频次、药性、核心处方等。结果 最终纳入142个医案。中药频次结果显示共得到高频中药14种，包括地龙、川芎、桃仁等，药物多为温、平、苦、甘，归肝、肺经者；四诊症状频次结果显示弦脉、舌红的频数最多。关联规则分析共得到药组关联规则24条，四诊症状-中药关联规则18条。结论 国医大师治疗脑卒中急性期多以清热息风、活血化瘀、豁痰开窍为法，治疗在活血化瘀基础上兼顾行气，在息风基础上兼顾通络止痉。

Objective To explore the prescription medication rule of the first batch of Chinese medicine masters in treating acute stage of stroke by using the data mining method. Methods The experience books and published journal articles of Chinese medicine masters and the shared medical records of national famous TCM studios in the cloud platform V1.5 of ancient and modern medical records were searched; The first batch of national physician master data for the treatment of acute phase of stroke was selected; A standardized basis database, standardization of medicines were established after using statistical analysis of system integration, association rules analysis, methods of complex networks; The formula frequency, medicinal, and core prescription drugs were analyzed. Results A total of 142 medical cases were eventually included. The frequency results of traditional Chinese medicine showed that 14 kinds of high-frequency traditional Chinese medicine were obtained, including Pheretima, Chuanxiong Rhizoma, Persicae Semen, etc., and most of the drugs were warm, smooth, bitter, sweet, and return to liver and lung meristem. The results showed that the frequency of chordal pulse and tongue red was the most. A total of 24 association rules and 18 TCM association rules were obtained by association rule analysis. Conclusion In the treatment of acute apoplexy, the Chinese medicine master usually adopted the methods of clearing heat and relieving wind, promoting blood circulation and removing blood stasis, eliminating phlegm and resuscitative medicinal, moving qi, and dredging collaterals, and stopping convulsions.

R28

国家中医药管理局刘茂才广东省全国名中医传承工作项目（粤中医办函〔2018〕5号）；广东省中医药局刘茂才广东省全国名中医传承工作项目（粤中医办函〔2018〕5号）；广东省中医院中医学术流派传承工作室建设项目：岭南林夏泉学术流派传承工作室资助（E43604）