当前临床常用的肿瘤化疗药物在杀伤癌细胞的同时，对正常组织细胞也有较强的毒副作用。虽然靶向和抗体抗肿瘤药物在临床上取得一定进展，但医疗成本高昂，很多患者难以承受。在不增加医疗和药品研发成本前提下，如何从天然产物中寻找高效、低毒、选择性强的抗肿瘤活性物质依然是目前研究的热点。对近年来具有选择性细胞毒作用的天然产物进行综述，为该类药物的基础研究和临床开发提供思路。

At present, anti-tumor chemotherapy drugs used in clinic commonly have serious side effects on normal tissues. Although targeted and antibody anti-tumor drugs have made progress in clinic, the high medical cost makes it difficult for many patients to afford. To find effective and low toxic anti-tumor agents without increasing medical cost, it is still the challenges of current research. Based on the natural products with selective cytotoxicity, we aimed to summarize the research progress, provide ideas for the basic research and clinical development of antitumor agents.

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中华中医药学会青年人才托举工程项目（CACM-2018-QNRC2-B08）；中央高校基本科研业务费（BUCM-2019-JCRC002）；中央高校基本科研业务费（2019-JYB-TD005）；中央高校基本科研业务费（2020-JYB-ZDGG-044）；国家自然科学基金资助项目（81603256）；北京市自然科学基金面上项目（7202116）；国家药品监督管理局课题资助（NMPA 2019-2020）