开心散由人参、远志、石菖蒲、茯苓4味传统药物组成，主治健忘、神智不宁、失眠多梦等症状，是宁心安神、健脾益智的代表方剂。其主要活性成分有人参皂苷类、远志皂苷和寡糖酯类、细辛醚、茯苓酸、茯苓多糖等。现代药理研究表明，开心散具有抗抑郁、抗痴呆、改善认知、抗疲劳等作用。通过查阅国内外与开心散相关的文献报道，对开心散抗抑郁、改善学习记忆能力的药理活性及作用机制的研究进展进行综述，并对其潜在的神经精神疾病的临床治疗方向进行展望。

Kaixin Powder, an ancient Chinese herbal decoction and is composed of Ginseng Radix et Rhizoma, Polygalae Radix, Acori Tatarinowii Rhizoma, and Poria Cocos. Its main active chemical components are ginseng ginsenosides, polygalae saponins, oligosaccharide esters, asarone, poria acid, and pachymaran, which have a variety of pharmacological effects such as anti-depression, anti-dementia, improving learning and memory, and anti-fatigue. This article mainly reviewed the literature related to Kaixin Powder published in domestic and foreign research journals, summarized the research on the pharmacological activity and their mechanisms of Kaixin Powder, and prospected the potential clinical application in the treatment of mental illness.

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国家科技部重大新药创制（2017ZX09301029）；科技部政府间科技合作（2016YFE0131800）