目的 对不同产地的锁阳Cynomorium songaricum药材进行产地鉴别与综合评价，为锁阳药材质量评价与产地适宜性的确定提供参考。方法 收集全国5省（区）的40批样品，测定锁阳中没食子酸、原儿茶酸、儿茶素、总多糖、总黄酮、Na、K、Ca、Mg、Fe、Zn、Mn、Co、Sr、Ni、Ag、Ba、Ti、Cu、Pb、Cr、Cd、As、Hg含量，运用正交偏最小二乘判别分析法（OPLS-DA）和熵权TOPSIS法对反映药材质量的数据进行分析。结果 锁阳中儿茶素、原儿茶酸、总黄酮、Mn、Zn、Co、Pb、Cr、Ca、Ti、Mg和Cu的含量差异可用于不同产地的区分；5个省（区）中内蒙古地区的锁阳药材质量最优，其次为甘肃、宁夏、新疆、青海。结论 OPLS-DA结合熵权TOPSIS分析法结果合理、客观、有效，可应用于锁阳药材质量的多指标综合评价。

Objective To identify and comprehensively evaluate Cynomorium songaricum from different producing areas in order to provide reference for the quality evaluation of C. songaricum and the determination of the suitability of the origin. Methods A total of 40 samples from five provinces (regions) were collected to measure the content of gallic acid, protocatechuic acid, catechins, total polysaccharides, total flavonoids, Na, K, Ca, Mg, Fe, Zn, Mn, Co, Sr, Ni, Ag, Ba, Ti, Cu, Pb, Cr, Cd, As, and Hg. The data reflecting the quality of C. songaricum were analyzed by orthogonal partial least squares discriminant analysis (OPLS-DA) and entropy weight TOPSIS analysis. Results The contents of Mn, Zn, Co, catechin, Pb, Cr, Ca, Ti, total flavonoids, protocatechuic acid, Mg and Cu in C. songaricum are important for distinguishing different producing areas. The quality of C. songaricum in Inner Mongolia was the best in all provinces (regions), followed by Gansu, Ningxia, Xinjiang, and Qinghai Provinces. Conclusion The results of OPLS-DA combined with entropy weight TOPSIS analysis are reasonable, objective and effective, and can be applied to the comprehensive evaluation of multiple indicators of C. songaricum.

R282.2

甘肃省中药药理与毒理学重点实验室基金项目（ZDSYS-KJ-2018-010）；甘肃省中药质量与标准研究重点实验室基金项目（ZYZL18-004）