川贝母因其药用效果良好，被中国及世界上多个国家广泛应用于临床治疗中。但是随着川贝母药材资源需求量的急剧增长及其野生基原植物存在产量低，自然条件下种子数量少、发芽率及成活率极低等缺陷，使得川贝母野生基原植物资源处于濒危状态。以中国知网和Web of Science这两大数据库所发表的文章为基础，综述了川贝母本草学考证、野生基原植物资源分布状况及其影响因素、保育措施及利用内生真菌获得贝母类生物碱等方面的研究进展。以期从传统的保育措施及现阶段积极探索的微生物提取活性物质的角度为川贝母野生基原植物资源的保育提供发展思路，以期早日实现川贝母的供需平衡。

Genuine medicinal materials—Fritillariae Cirrhosae Bulbus and its active components are widely used in clinical medicine in China and even in many countries in the world because of their good medicinal effect. However, with the increase of the demand for the resources of Fritillariae Cirrhosae Bulbus, and the low yield of itself, the small number of seeds under natural conditions, the extremely low germination rate and survival rate and so on, the wild resources of Fritillariae Cirrhosae Bulbus are endangered. This paper summarized researches of several aspects like herbal research of Fritillariae Cirrhosae Bulbus, distribution of wild source plant resources and its influencing factors, conservation measures, and using endophyte to extract Fritillaria alkaloids, based on the articles published by China National Knowledge Internet and Web of Science. Hoping to provide some development ideas for the protection of wild source plant resources of Fritillariae Cirrhosae Bulbus from the perspectives of traditional conservation measures and active products extracted by microbial vigorously developed at this stage, so as to realize the balance of supply and demand of Fritillariae Cirrhosae Bulbus as soon as possible.

R282

2019年医疗服务与保障能力提升补助资金（中医药事业传承与发展部分）“全国中药资源普查项目”（财社[2019]39号）；西华师范大学博士科研启动经费（18Q045）；西华师范大学校基本科研业务费（19B034）