目的 研究紫茎泽兰Eupatorium adenophorum的化学成分。方法 应用多种色谱方法对紫茎泽兰乙醇提取物的醋酸乙酯部位进行分离纯化，结合波谱技术与化学方法进行结构鉴定。结果 从紫茎泽兰乙醇提取物的醋酸乙酯部位中分离得到14个化合物，分别鉴定为对羟基苯甲酸乙酯（1）、（1R，4R）-8aα-羟基-1-异丙基-4，7-二甲基-1，2，3，4，6，8a-六氢-萘-2，6-二酮（2）、daedalin A（3）、10-氧-7-羟基-去甲去氢丙呋甲酮（4）、咖啡酸乙酯（5）、丁香酸（6）、3-羟基-4-乙酰基苯甲酸（7）、阿魏酸（8）、对羟基苯乙醇（9）、原儿茶酸乙酯（10）、4-羟基-3-异丙基苯甲酸（11）、蛇菰宁（12）、3-吲哚甲酸（13）、6-甲氧基山柰酚（14）。结论 化合物11为首次从天然产物中分离得到，化合物1、3、6、7、9、10、12～14为首次从泽兰属分离得到，化合物5为首次从该植物中分离得到。

Objective To study the chemical constituents of the Eupatorium adenophorum. Methods The chemical constituents were isolated and purified by silica gel chromatography repeatedly from the ethyl acetate extract of E. adenophorum, and their structures were identified by spectral analysis and chemical methods. Results Fourteen compounds were isolated from E. adenophorum and identified as p-hydroxybenzoic acid ethyl ester (1), (1R,4R)-8aα-hydroxy-1-isopropyl-4,7-dimethyl-1,2,3,4,6,8a-hexahydro-naphthalene-2,6-dione (2), daedalin A (3), 10-oxo-7-hydroxy-nordehydrotremetone (4), caffeoyl acetate (5), syringic acid (6), 3-hydroxy-4-(1-oxo-ethane)-benzoic acid (7), ferulic acid (8), p-hydroxyphenylethyl alcohol (9), protocatechuic acid ethyl ester (10), 4-hydroxy-3-isopropyl benzoic acid (11), balanophonin (12), indole-3-carboxylic acid (13), and 6-methoxy kaempferol (14). Conclusion Compound 11 is obtained from natural products for the first time, compounds 1, 3, 6, 7, 9, 10, 12-14 are obtained from this genus for the first time, and compound 5 is obtained from this plant for the first time.

R284.1

国家自然科学基金项目“基于STAT-3靶点的泽兰属两种外来入侵植物抗肝癌药效物质基础及作用机理研究”（81660656）；国家自然科学基金项目“民族药石上柏作用于喉癌COX-2和EGFR多靶标的活性成分及作用机制研究”（81774000）