目的 研究掌叶大黄Rheum palmatum根中鞣质类化学成分。方法 采用硅胶柱色谱、中压柱色谱及半制备高效液相色谱等多种色谱分离方法对鞣质类成分进行分离，根据波谱数据分析鉴定化合物结构。结果 从掌叶大黄的70%乙醇提取物中分离得到4个鞣质类化合物，分别鉴定为3-O-桂皮酰基-1-O-没食子酰基-β-D-葡萄糖苷（1）、2-O-桂皮酰基-1-O-没食子酰基-β-D-葡萄糖苷（2）、2-O-桂皮酰基-1，6-O-二没食子酰基-β-D-葡萄糖苷（3）、6-O-桂皮酰基-1-O-没食子酰基-β-D-葡萄糖苷（4）。结论 化合物1为新化合物，命名为掌叶大黄苷。

Objective To study the chemical constituents of tannin from the roots of Rheum palmatum. Methods Chemical constituents of tannins were isolated by silica gel column chromatography, medium pressure column chromatography, and semi-preparative HPLC from the roots of R. palmatum. The structures were elucidated on the basis of spectral data analysis. Results Four tannins, 3-O-cinnamoyl-1-O-galloyl-β-D-glucopyranoside (1), 2-O-cinnamoyl-1-O-galloyl-β-D-glucopyranoside (2), 2-O-cinnamoyl-1,6-di-O-galloyl-β-D-glucopyranoside (3), and 6-O-cinnamoyl-1-O-galloyl-β-D-glucopyranoside (4) were isolated from the roots of R. palmatum. Conclusion Compound 1 is a new compound named palmatoside.

R284.1

国家自然科学基金-河南省联合基金（U1604192）；河南省高校科技创新人才支持计划项目（20HASTIT008）