目的 收集清肺排毒汤（QFPDT）的主要活性成分、靶标，探讨其靶标与新型冠状病毒肺炎（COVID-19）之间的联系以及多成分、多靶标的治疗机制。方法 从ETCM、TCMID、NPASS数据库搜索QFPDT每味中药的归经、成分和靶标，用Cytoscape软件构建和分析网络，用DAVID和STRING对靶标进行功能富集分析。结果 QFPDT里的中药大多数归肺经，其790个潜在靶标中的232个与新型冠状病毒（SARS-CoV-2）的受体血管紧张素转化酶II（ACE2）是共表达的；靶标包含7个两两相互作用的核糖体蛋白；重要靶标富集在病毒感染和肺部损伤2大类疾病通路上，且与HIV病毒的6个蛋白具有密切的相互作用；重要靶标调控内分泌系统、免疫系统、信号转导、翻译等生物学过程的一系列信号通路。结论 QFPDT通过多成分、多靶标对机体起到整体调控作用。其首要作用部位是肺，其次是脾；通过调控若干与ACE2共表达的蛋白以及与疾病发生发展密切相关的一系列信号通路，起到平衡免疫、消除炎症的作用；靶向病毒复制必需的蛋白——核糖体蛋白而抑制病毒mRNA翻译，并抑制与病毒蛋白相互作用的蛋白而起到抗病毒作用。

Objective To collect main ingredients and targets of Qing-Fei-Pai-Du-Tang (QFPDT), and to investigate the relationship between the targets and coronavirus disease 2019 (COVID-19) and the multi-component, multi-target mechanism of QFPDT for the treatment of COVID-19. Methods The meridian tropisms, compounds and targets of each herb in QFPDT were collected from ETCM, TCMID and NPASS databases. Cytoscape software was used to construct and analyze networks. DAVID and STRING were applied for functional enrichment analysis of targets. Results The top meridian tropism of herbs in QFPDT was lung meridian. Among QFPDT's 790 putative targets, 232 targets were co-expressed with ACE2, the receptor of novel coronavirus (SARS-CoV-2). The targets included seven densely interacting ribosomal proteins. Important targets were enriched on two classes of disease pathways, i.e., virus infection and lung injury. In addition, many targets interacted with six proteins of HIV virus. Important targets regulated a series of pathways belong to translation, endocrine system, immune system, nervous system and signal transduction. Conclusion The main targeting organ of QFPDT is the lung and the second is the spleen. By regulating a series of proteins co-expressed with ACE2 and a series of signaling pathways closely related to the occurrence and development of diseases, it plays a role in balancing immunity and eliminating inflammation. It may act as an antiviral agent by targeting ribosomal proteins that are necessary for viral replication to inhibit viral mRNA translation and inhibiting a group of proteins that interact with viral proteins.

国家重点研发计划项目（2020YFC0845400）；国家重点研发计划项目（2017YFC1700200）