附子为常用中药，具有回阳救逆、散寒止痛、温阳化气的功效。C₁₉二萜生物碱是其主要生物碱类成分，可分为双酯型、单酯型和胺醇型，其在发挥抗炎、镇痛、抗肿瘤等药效同时，也可导致心脏毒性和神经毒性。对附子C₁₉二萜生物碱化学结构、药理及毒理作用进行系统梳理，以期为临床更安全、有效地使用附子提供理论依据。

Aconiti Lateralis Radix Praeparata (Fuzi in Chinese) is a commonly used Chinese materia medica in clinic, with the effects in rescuing from collapse by restoring yang, eliminating cold to stop pain, warming yang and transforming qi. C₁₉ diterpenoid alkaloids from Fuzi can be divided into three types:diester type, monoester type and amine alcohol type, which can lead to neurotoxicity and cardiotoxicity while exerting anti-inflammatory, analgesic, anti-tumor and other pharmacodynamic effects. In this paper, the chemical structure, pharmacology and toxicological effects of C₁₉ diterpene alkaloids of Fuzi were systematically combed, in order to provide a theoretical basis for safer and more effective use of Fuzi in clinic.

R282.71

国家自然科学基金资助项目（81873220）；国家自然科学基金资助项目（81774167）；山东省重点研发计划（2018CXGC1307）；山东省中医药科技发展计划（2015-013）；山东省中医药科技发展计划（2013-026）