目的 对胡芦巴Trigonella foenum-graecum的化学成分进行研究。方法 运用Sephadex LH-20凝胶、硅胶柱色谱、半制备高效液相色谱等多种色谱技术进行分离和纯化，并通过其理化性质和NMR数据综合分析，鉴定化合物结构。结果 从胡芦巴乙醇提取物中得到6个甾体皂苷类和黄酮类化合物，分别为22-甲氧基-胡芦巴皂苷IIb（1）、芰脱皂苷元（2）、薯蓣皂苷元（3）、木犀草素（4）、木犀草苷（5）、木犀草素-7-O-芸香糖苷（6）。结论 化合物1为新化合物，化合物5和6是从该植物中首次分离得到。

Objective To research the chemical constituents from Trigonella foenum-graecum. Methods The chemical constituents were separated and purified by sephadex LH-20, silica gel, semi-prepared HPLC and other chromatography techniques. Their structures were elucidated by their physicochemical properties and NMR data. Results Six steroidal saponins and flavonoids (1-6) were isolated from the ethanol extracts of T. foenum-graecum and identified as 22-methoxy-trigoneoside IIb (1), gitogenin (2), diosgenin (3), luteolin (4), cynaroside (5), and luteolin-7-O-rutinoside (6). Conclusion Compound 1 is a new compound, and compounds 5 and 6 are obtained for the first time from T. foenum-graecum.

天津市自然科学基金重点项目（16JCZDJC32600）；中国博士后基金资助项目（2016M591399）