目的 研究黄精Polygonatum sibiricum根茎的化学成分。方法 运用HP-20大孔吸附树脂、硅胶、ODS和Sephadex LH-20等柱色谱以及反相制备型HPLC等各种现代色谱分离技术进行系统地分离纯化，根据化合物的光谱数据和理化性质进行结构鉴定。结果 从黄精根茎95%乙醇提取物中分离得到5个化合物，分别鉴定为黄精新木脂素苷A（1）、（+）-异落叶松脂素-9'-O-β-D-葡萄糖苷（2）、反式-N-p-香豆酰基酪胺（3）、3-（4-羟基苯基）-N-[2-（4-羟基苯基）-2-甲氧基乙基]丙烯酰胺（4）、3-（4-羟基-3-甲氧基苯基）-N-[2-（4-羟基苯基）-2-甲氧基乙基]丙烯酰胺（5）。结论 化合物1为1个新的苯骈呋喃型木脂素，命名为黄精新木脂素苷A，化合物2～5为首次从该植物中分离得到。

Objective To isolate and identify the chemical constituents from the rhizomes of Polygonatum sibiricum. Methods The compounds were isolated and purified by various modern chromatographies, and their structures were identified by physiochemical properties and spectroscopic data. Results Five compounds were isolated from the EtOH extract of the rhizomes of P. sibiricum, which were elucidated as polygonneolignanoside A (1), (+)-isolariciresinol-9'-O-β-D-glucopyranoside (2), trans-N-p-coumaroyltramine (3), 3-(4-hydroxyphenyl)-N-[2-(4-hydroxyphenyl)-2-methoxyethyl]acrylamide (4), 3-(4-hydroxy-3-methoxyphenyl)-N-[2-(4-hydroxyphenyl)-2-methoxyethyl]acrylamide (5). Conclusion Among them, compound 1 was a new benzofuran lignan, and compounds 2-5 were isolated from this plant for the first time.

国家自然科学基金资助项目（21602047）；南阳理工学院河南省张仲景方药与免疫调节重点实验室开放课题（KFKT2018-2）；河南省高等学校青年骨干教师资助计划（2017GGJS-081）