目的 从含亚精胺植物中筛选出一种对平阳霉素发酵起促进作用的植物药。方法 以生物发酵中碳氮源筛选手段为基础，通过HPLC在黑枸杞、宁夏枸杞、宁夏枸杞嫩芽、红花和薏米等中药材中筛选出对平阳霉素生物合成促进效果最佳的植物药，并筛选出最佳的添加时间、添加量以及添加频率。结果 筛选得到宁夏枸杞嫩芽对平阳霉素发酵效果最佳，且初始添加时间为24 h，添加间隔为24 h，添加频率为3次时效果最佳。每次添加量为7 g/L时其摇瓶发酵水平为21.3 μg/mL，每次添加量为18 g/L时25 L罐发酵水平为37.5 μg/mL，较原始发酵效价分别提高了23.8%和118.0%，较添加亚精胺产率提高45.3%。结论 含亚精胺植物药大部分对平阳霉素发酵生产具有促进作用，筛选宁夏枸杞嫩芽作为平阳霉素发酵原材料从成本、产率以及环保角度均符合生产要求。

Objective Screening a plant medicine containing spermidine to promote the fermentation of pingyangmycin (PYM). Methods Based on the screening method of carbon and nitrogen sources in biological fermentation, the plant medicine with the best promotion effect on PYM was screened out by HPLC method in Lycium ruthenicum, Lycium barbarum, Lycium barbarum bud, Carthamus tinctorius, and Coicis Semen. And the best adding time, amount and frequency were also screened out. Results The results showed that Lycium barbarum bud had the best effect on PYM fermentation, and the initial adding time was 24 h, the adding interval was 24 h, and the adding frequency was three times. The shaking bottle fermentation level was 21.3 μg/mL when the addition amount was 7 g/L/per batch, and the 25 L tank fermentation level was 37.5 μg/mL when the addition amount was 18 g/L/per batch, which increased by 23.8% and 118.0%, respectively. Compared with the addition of spermidine, the yield was increased by 45.3%. Conclusion Most plant drugs containing spermidine can promote the fermentation of pingyangmycin, and the selection of Lycium barbarum bud as raw materials for pingyangmycin fermentation meets the production requirements in terms of cost, yield and environmental protection.