目的 对皱盖假芝Amauroderma rude子实体中的化学成分进行初步研究。方法 采用硅胶柱色谱、凝胶柱色谱、液相色谱等多种色谱方法对皱盖假芝子实体醋酸乙酯相中的化学成分进行分离纯化，并根据其理化性质和波谱数据鉴定化合物结构。结果 从皱盖假芝醋酸乙酯相中分离得到3个化合物，包括1个新的木脂素和2个已知的甾醇类化合物，分别鉴定为3，4-二羟基苯甲酰乙酰酮（1）、（22E，24R）-3β，5α-二氢-麦角甾-7，22-二烯-6-酮（2）、（22E，24R）-麦角甾-6，9，22-三烯-3β，5α，8α-三醇（3）。结论 化合物1为新的木脂素类成分，命名为假芝木脂素B。

Objective Study on the chemical constituents in the ethyl acetate phase extracted from the fruiting bodies of Amauroderma rude. Methods Silica gel column chromatography, Sephadex LH-20 gel and liquid chromatography were used to separate and purify the chemical constituents in fruiting bodies of Amauroderma rude. The compounds were identified according to their physical and chemical properties and spectroscopic data. Results Three compounds including one new lignan and two known sterols were isolated from the ethyl acetate phase of this fungus. Their structures were identified as 3,4-dihydroxyphenacyl acetyl ketone (1), (22E, 24R)-3β,5α-dihydrox-yerogosta-7,22-diene-6-one (2), and (22E,24R)-ergosta-6,9,22-trien-3β,5α,8α-triol (3). Conclusion Compound 1 was a new lignan and named amaurolignan B.

国家自然科学基金资助项目（31600282）