探讨治疗消化系统肿瘤处方的组方用药规律，将《肿瘤良方大全》中全部消化系统肿瘤处方录入Microsoft Excel 2010，建立数据库并进行频次、药对、中药类别统计，采用IBM SPSS Modeler 14.1进行关联分析，应用IBM SPSS Statistics 21予以聚类及因子分析。研究消化系统肿瘤处方501首，涉及中药651种。单味药以茯苓、陈皮、木香、当归的使用频次最高，对药以茯苓-白术、三棱-莪术、陈皮-木香的使用频次最高；中药类别以清热药、补虚药、活血化瘀药的使用频次最高；关联网络图发现三棱→莪术、白术→茯苓药对关联度最高；聚类分析发现12个中药组合；因子分析共提取出6个公因子，载荷最高的依次为白术、三棱、大黄。《肿瘤良方大全》所载消化系统肿瘤处方以消癥散结为核心大法，从理气、化湿，行气降逆以散浊；活血、益气，寓补于消以化瘀；清解、清热，攻毒活血以消积3个角度，通常达变，灵活用药。

To investigate the rule of prescription medication in the treatment of digestive system tumors. All the digestive system cancer prescriptions in Cancer Prescription Daquan were entered into Microsoft Excel 2010, the database was established and the frequency, drug pairs and categories of traditional Chinese medicine were counted. IBM SPSS Modeler 14.1 was used for correlation analysis, and IBM SPSS Statistics 21 was used for clustering and factor analysis. A total of 501 prescriptions for digestive system tumors were studied, involving 651 kinds of Chinese materia medica. Poria, Citri Reticulatae Pericarpium, Aucklandiae Radix, and Angelicae Sinensis Radix were the most frequently used drugs, and Poria-Atractylodis Macrocephalae Rhizoma, Sparganii Rhizoma-Curcumae Rhizoma, Citri Reticulatae Pericarpium-Aucklandiae Radix were the most frequently used drug pairs; Chinese herbal medicine categories of heat-clearing drugs, deficiency-tonifying drugs, blood-activating and stasis-removing drugs were the most frequently used. The highest frequency of Sparganii Rhizoma-Curcumae Rhizoma and Poria-Atractylodis Macrocephalae Rhizoma was found in correlation network diagram; Cluster analysis found 12 Chinese herbal medicine combinations; Six common factors were extracted from the analysis, and the highest loads in sequence were Atractylodis macrocephalae Rhizoma, Sparganii Rhizoma, and Rhei Radix et Rhizoma. The prescriptions of digestive system tumors contained in Cancer Prescription Daquan are based on the core of dispersing symptoms and resolving nodules. Its usually change and use flexibly drugs from three angles of regulating qi, removing dampness, promoting qi and reducing adverse reactions to disperse turbidity, activating blood circulation and benefiting qi, and eliminating blood stasis; clearing away heat, fighting toxins and activating blood circulation to resolve accumulate.

国家自然科学基金资助项目（81573627）；国家自然科学基金资助项目（81873021）