目的 对小花鬼针草Bidens parviflora全草的化学成分进行系统研究。方法 对小花鬼针草80%乙醇提取物的醋酸乙酯部位采用硅胶、聚酰胺、Sephadex LH-20及HPLC进行分离纯化，根据理化性质及波谱数据鉴定所得化合物的结构。结果 从小花鬼针草80%乙醇提取物中分离得到10个化合物，分别鉴定为（Z）-6-O-（4″-O-乙酰基-6″-O-p-香豆酰基-β-D-吡喃葡萄糖基）-6，7，3'，4'-四羟基橙酮（1）、奥卡宁-4'-O-β-D-（6″-乙酰基）-葡萄糖苷（2）、7，3'，4'-三羟基-6-O-（4″，6″-二乙酰基-β-D-吡喃葡萄糖基）-橙酮（3）、6，7，3'，4'-四羟基橙酮（4）、异奥卡宁（5）、丁香酸-4-O-α-L-鼠李吡喃糖苷（6）、奥卡宁-4'-O-β-D-（6″-反式-对-香豆酰基）-吡喃葡萄糖苷（7）、奥卡宁-4'-O-β-D-（4″-乙酰基-6″-反式-对-香豆酰基）-吡喃葡萄糖苷（8）、槲皮素-3，4'-二甲醚-7-O-芸香糖苷（9）、cordifolioidyne B（10）。结论 化合物1为1个新化合物，命名为鬼针草苷I，化合物6和10为首次从该属植物中分离得到，其他化合物为首次从该植物中分离得到。

Objective To study the chemical constituents of Bidens parviflora. Methods The ethyl acetate fraction of 80% ethanol extract from B. parviflora was isolated and purified by silica, polyamide, Sephadex LH-20, and HPLC, then the structures of obtained compounds were identified by physicochemical properties and spectral data. Results Ten compounds were isolated and identified as Z-6-O-(4″-O-acetyl-6″-O-p-coumaroyl-β-D-glucopyranosyl)-6,7,3',4'-tetrahydroxyaurone (1), okanin-4'-O-β-D-(6″-O-acetyl)-glucoside (2), Z-6-O-(4″,6″-diacetyl-β-D-)-7,3',4'-tetrahydroxy aurone (3), 6,7,3',4'-tetrahydroxy aurone (4), isookanin (5), syringic acid-4-O-α-L-rhamnopyranoside (6), okanin-4'-O-β-D-(6″-trans-p-coumaroyl)-glucoside (7), okanin-4'-O-β-D-(4″-acetyl-6″-trans-p-coumaroyl)-glucoside (8), quercetin-3,4'-dimethyl ether-7-O-rutinoside (9), and cordifolioidyne B (10). Conclusion Compound 1 is a new compound named as bidenoside I, compounds 6 and 10 are isolated from the genus Bidens for the first time, other compounds are isolated from this plant for the first time.

山东省中医药科技发展计划（2019-0315）；山东省重点研发计划项目（2017GSF19105）