"反"是中药"十八反"概念的重心，目前中医药界专家的观点普遍倾向于认为"反"是相对的，即在一定条件下可发生配伍禁忌和适宜配伍之间的转换。芫花-甘草反药组合是"十八反"的代表性组合之一，研究的也较为充分。从物质基础、药理毒理、药物代谢及代谢组学、配伍禁忌机制、肠道菌群、临床应用和配伍宜忌条件7个方面分析总结了芫花-甘草反药组合的研究进展，并结合芫花化学成分的系统研究，从活性成分间弱键作用角度探讨芫花-甘草配伍物质基础的内涵，为该反药组合的进一步研究提供参考。

"Incompatibility" is the focus of the "Eighteen Incompatible Medicaments" in Chinese materia medica. At present, most experts in traditional Chinese medicine supported that "incompatibility" is relative, that is, the conversion between incompatibility and appropriate compatibility can occur under certain conditions. Genkwa Flos and Glycyrrhizae Radix et Rhizoma are one of the representative of incompatible pairs in "Eighteen Incompatible Medicaments", which had been well studied. This paper summarized the research progress of the incompatible pairs of Genkwa Flos and Glycyrrhizae Radix et Rhizoma from seven aspects of material basis, pharmacological toxicology, drug metabolism and metabolomics, incompatibility mechanism, gut microbiota, clinical application and compatibility conditions. Combined with the author's previous systematic study on the chemical components of Daphne genkwa, the connotation of the material base of Genkwa Flos and Glycyrrhizae Radix et Rhizoma was discussed from the perspective of the weak bond between the active components in this paper, so as to provide reference for further research of the incompatible pair.

国家自然科学基金项目（81603256）；中央高校基金科研业务项目——岐黄团队（2019-JYB-TD005，BUCM-2018-2020）；中央高校基金科研业务项目——杰出青年基金（BUCM-2019-JCRC002）；中央高校基金科研业务项目——青年教师项目（2019-JYB-JS-018）；北京中药基础与新药研究重点实验室项目（100102）；中华中医药学会青年人才托举工程项目（CACM-2018-QNRC2-B08）