目的 研究窝儿七Diphylleia sinensis中的木脂素类化学成分。方法 采用硅胶和葡聚糖凝胶柱色谱以及半制备液相色谱等方法分离纯化，结合1D/2D NMR、MS、IR等波谱技术鉴定化合物结构。结果 从窝儿七中共分离得到7个木脂素，分别鉴定为山荷叶素A（1）、（1S，2R，5S，6R）-2-（4-hydroxyphenyl）-6-（3-methoxy-4-hydroxyphenyl）-3，7-dioxabicyclo[3.3.0]octane（2）、（7S，8R，7'S，8'R）-3，4，3'，4'-tetramethoxy-9，7-dihydroxy-8.8'，7.O.9'-lignan（3）、（-）-落叶松脂醇（4）、vladinol D（5）、鬼臼毒酮（6）、爵床脂素A（7）。结论 化合物1为新化合物，化合物2~4首次从窝儿七中分离鉴定。

Objective To investigate the lignans of the roots of Diphylleia sinensis. Methods The chemical components were isolated and purified by chromatographic techniques (silica gel, sephadex LH-20 and semi preparative-HPLC) and the chemical structures were determined by spectral data analysis (1D/2D NMR, MS, and IR). Results Seven lignans were obtained and identified as diphyllin A (1), (1S,2R,5S,6R)-2-(4-hydroxyphenyl)-6-(3-methoxy-4-hydroxyphenyl)-3,7-dioxabicyclo[3.3.0] octane (2), (7S,8R,7'S,8'R)-3,4,3',4'-tetramethoxy-9,7-dihydroxy-8.8',7.O.9'-lignan (3), (-)-lariciresinol (4), vladinol D (5), podophyllotoxone (6), and justicidin A (7). Conclusion Diphyllin A (1) is a new compound and 2-4 are obtained from D. sinensis for the first time.

陕西省教育厅自然科学项目（16JK121）