基于质量标志物（Q-marker）的概念、确定标准及研究模式来研究白术质量标志物，通过对白术化学物质组辨识明确化学物质基础；通过白术化学成分生源途径及成分特异性分析明确其化学成分的来源及特异性；通过药效、药性及其物质基础的相关性分析，明确其主要药效物质基础；并综合研究结果，推测白术可能的质量标志物。

To study the quality marker (Q-marker) of Atractylodes macrocephala based on the concept, standard, and research model of Q-marker. The chemical constituents of A. macrocephala were identified by UPLC-Q-TOF-MS/MS. The source and specificity of chemical constituents were confirmed by analyzing biosynthetic pathway and component specificity. The major effective components were clarified through efficacy, drug property, and correlation analysis of chemical constituents. The possible Q-markers of A. macrocephala are estimated based on the results of the study.

2016-2018年安徽高校科研平台创新团队："现代中药质量控制研究"项目资助（2016HZ23）；2019安徽省重点研究与开发计划项目：安徽道地珍稀濒危药材祁术的保护与开发研究（201904a07020061）