磷脂酰肌醇3激酶（PI3K）/蛋白激酶B（Akt）信号通路是调节机体内细胞存活、分化及凋亡的重要信号通路之一，在癌症、糖尿病、神经系统疾病等的发生及相关药物作用机制研究中具有重要作用。近年来，人们逐渐开始关注该通路在抑郁症以及抗抑郁中药作用机制研究中的作用。对PI3K/Akt信号通路关键靶标与抑郁症的关系、PI3K/Akt信号通路在抑郁症中的作用以及PI3K/Akt信号通路在抗抑郁中药作用机制研究中的进展进行综述，为抑郁症的治疗及抗抑郁药物研发提供参考依据。

The phosphatidylinositol 3 kinase (PI3K)/protein kinase B (Akt) signaling pathway is one of the important signaling pathways for regulating cell survival, differentiation and apoptosis in vivo, which plays an important role in the occurrence of cancer, diabetes, nervous system diseases and the mechanisms of related drugs. In recent years, attention has been paid to the role of PI3K/Akt signaling pathway in the study of depression and the mechanism of antidepressant traditional Chinese medicine. This article reviews the relationship between key targets of PI3K/Akt signaling pathway and depression, the role of PI3K/Akt signaling pathway in depression and PI3K/Akt signaling pathway in the study of mechanism of antidepressant traditional Chinese medicine, which provides a reference for the treatment of depression and the discovery of antidepressant drugs.

国家"重大新药创制"科技重大专项（2017ZX09301047）；山西省科技重点研发计划（201603D3113013）；山西省科技重点研发计划（201603D321077）；山西省科技重点研发计划（201701D121137）；地产中药功效物质研究与利用山西省重点实验室项目（201605D111004）；山西省科技创新重点团队项目（201605D131045-18）