目的 优化筛选益气活血方的水提工艺参数。方法 在单因素实验基础上，采用正交试验设计，以加水量、提取时间、浸泡时间为考察因素，丹酚酸B和羟基红花黄色素A的转移率及浸膏得率为评价指标，采用G1-熵权法赋权得到综合评分。通过正交试验设计进行分析得到最佳水提工艺，再通过BP神经网络建模进行网络模型优化和目标寻优。验证试验对比2种分析方法，寻找益气活血方的最佳水提工艺参数。结果 基于2种分析方法对比发现，正交试验分析得到最佳水提工艺的综合评分略高于BP神经网络建模结果，故最终确定该益气活血方最佳水提工艺参数为水提3次、浸泡0.5 h、加水量20倍、提取时间3.5 h。结论 优选出的益气活血方水提最佳工艺稳定可行，为复方中药的新药开发和现代化研究提供了新的思路和参考。

Objective To optimize the water extraction technology parameters of Yiqi Huoxue Prescription (YHP). Methods On the basis of single factor experiment, orthogonal experiment design was used to evaluate the transfer rate and extraction yield of salvianolic acid B and hydroxysafflower yellow A by using adding water, extraction time and soaking time as factors. The comprehensive score was obtained by G1-entropy weight method. The optimal water extraction technology was obtained by orthogonal test design, and another method-BP neural network modeling was used to optimize the network model and target optimization. The two analytical methods were compared in the verification experiment to find the optimal water extraction technology parameters of YHP. Results Based on the comparison of the two analytical methods, it was found that the comprehensive score of the optimal water extraction technology obtained by orthogonal test analysis was slightly higher than that obtained by BP neural network modeling. Therefore, it was finally determined that the optimal water extraction technology parameters of YHP were as follow:water extraction for three times, soaking for 0.5 h, adding water of 20 times, and extracting time for 3.5 h. Conclusion The optimal water extraction technology of YHP is stable and feasible, which provides new ideas and references for the development and modernization of new drugs of compound Chinese medicine.

国家自然科学基金资助项目（81673955）；湖南省自然科学基金资助项目（2017JJ2206）；湖南中医药大学中药学一流学科建设项目（4901-0200002006）