目的 研究川东獐牙菜Swertia davidii的化学成分。方法 采用多种色谱方法进行化学成分的分离纯化，通过NMR光谱数据分析和与已有物质对比分析进行化合物结构鉴定。结果 从川东獐牙菜70%乙醇提取物的醋酸乙酯部位中，分离鉴定了17个已知化合物，包括3个少见的内酯烯胺酮、5个（口山）酮、5个环烯醚萜苷和4个其他类化合物，分别鉴定为gentiocrucine（1）、gentiocrucine A（2）、gentiocrucine B（3）、junipediol A（4）、1-羟基-3，4，7，8-四甲氧基（口山）酮（5）、1，7，8-三羟基-3-甲氧基（口山）酮（6）、1，8-二羟基-3，4，7-三甲氧基（口山）酮（7）、1，5，8-三羟基-3-甲氧基（口山）酮（8）、当药醇苷（9）、去乙酰德苦草苦苷（10）、苦龙胆酯苷（11）、羟基当药苦酯苷（12）、獐牙菜苦苷（13）、龙胆苦苷（14）、齐墩果酸（15）、胡萝卜苷（16）、β-谷甾醇（17）。结论 化合物1~6、10、12、16和17为首次从该植物中分离得到。

Objective To study the chemical constituents from Swertia davidii. Methods The chemical constituents of the ethyl acetate fraction from the whole plants of S. davidii (Gentianaceae) were investigated by various chromatographic methods including silica gel, ODS, semi-preparative HPLC and so on. Their structures were identified on the basis of NMR spectral data analysis and comparisons with the data reported in literatures. Results Seventeen known compounds were separated and purified from the ethyl acetate fraction of this plant, which were identified as gentiocrucine (1), gentiocrucine A (2), gentiocrucine B (3), junipediol A (4), 1-hydroxy-3,4,7,8-tetramethoxyxanthone (5), 1,7,8-trihydroxy-3-methoxyxanthone (6), 1,8-dihydroxy-3,4,7-trimethoxyxanthone (7), 1,5,8-trihydroxy-3-methoxyxanthone (8), swertianolin (9), deacetylcentapicrin (10), amarogentin (11), amaroswerin (12), swertiamarin (13), gentiopicroside (14), oleanolic acid (15), daucosterol (16), and β-sitosterol (17). Conclusion Compounds 1-6, 10, 12, 16, and 17 are isolated from S. davidii for the first time.

重庆市科委基础科学与前沿技术研究（cstc2016jcyjA0056）；长江师范学院青年科技人才成长计划（2016QNRC02）