目的 考察鱼腥草破壁饮片抗内毒素（LPS）作用，并与传统饮片作用进行比较。方法 采用BALB/c小鼠鼻滴LPS建立肺部炎症模型，检测血液中炎症细胞数和病理学观察肺组织炎症程度；采用尾iv内毒素致大鼠炎症模型，检测血液中白细胞数和血浆中LPS含量，酶联免疫法（ELISA）检测血清中炎症因子IL-1β、IL-6、TNF-α含量；采用鲎试剂试验法，观察鱼腥草破壁饮片提取物体外抗细菌内毒素作用。结果 鱼腥草破壁饮片和传统饮片均可不同程度降低BALB/c小鼠全血中白细胞含量，减轻肺组织病理炎症细胞浸润，且破壁饮片呈明显的剂量依赖关系；鱼腥草破壁饮片与传统饮片均可不同程度显著降低大鼠全血中白细胞、血浆中内毒素和血清中IL-6、IL-1β和TNF-α含量；与传统饮片比较，鱼腥草破壁饮片可明显降低血清中IL-1β、TNF-α含量；相同剂量或相同稀释比例下，鱼腥草破壁饮片体外抗细菌内毒素作用均显著强于鱼腥草传统饮片。结论 鱼腥草破壁饮片具有良好的抗内毒素作用，且在一定程度上优于鱼腥草传统饮片。

Objective To study the anti-lipopolysaccharide (LPS) effect of the ultrafine granular powder of Houttuynia cordata and the effects in comparison with traditional decoction pieces. Methods BALB/c mice were injected with LPS through nose to establish lung inflammation model. The number of leukocytes in mice whole blood was examined, and the degree of the inflammation of lung tissue by pathology was observed. Rat inflammatory model was induced by injection of LPS into tail vein. The number of leukocytes in mice whole blood, content of LPS in plasma were examined, the content of IL-1β, IL-6, and TNF-α in serum were detected by enzyme-linked immunoadsordent assay (ELISA). The limulus test method was used to detect the anti-lipopolysaccharide effect of the ultrafine granular powder of H. cordata in vitro. Results The ultrafine granular powder of H. cordata and traditional decoction pieces can reduce the level of leukocytes in mice whole blood in various degrees, and alleviated the infiltration of inflammatory cells in pathological lung tissue, and there was a positive dosage dependent relation. For the two decoction pieces, the number of leukocytes in rat whole blood, the content of LPS in plasma, the levels of IL-1β, IL-6, and TNF-α in serum decreased in different degrees were found. Compared with traditional decoction pieces group, the content of IL-1β and TNF-α of serum in ultrafine granular powder group were significant decreased. The ultrafine granular powder of H. cordata showed better anti-inflammatory activity than traditional decoction pieces in vitro at the same concentration and same dilution ratio. Conclusion The ultrafine granular powder of H. cordata has satisfactory anti-lipopolysaccharide effect, and the effect is better than traditional decoction pieces in some extent.

广东省省级科技计划项目：中山火炬高新区数字医疗与健康科技产业集群中药质量研究平台建设（2014B010108013）；中山市协同创新专项资金项目：中山市中药破壁饮片技术与应用协同创新中心（2016C1014）