紫草素是从草本植物紫草Arnebiae Radix中提取的一种具有抗炎、抗病毒、抗肿瘤、促伤口愈合等生物活性的萘醌类化合物。近年来，紫草素及其衍生物的抗肿瘤作用被广泛研究。从构效关系、抗肿瘤作用机制等方面综述近5年紫草素及其衍生物的抗肿瘤作用的研究进展，以期为紫草素类化合物的研究及利用提供参考。

Shikonin is a naphthoquinone compound extracted from natural plant Arnebiae Radix, which has various biological activities of anti-inflammation, antivirus, anti-tumor and promoting wound healing. The antitumor activity of shikonin and its derivatives have received widely attention in recent years. In this study, we have reviewed the advances in anti-tumor effects of shikonin and its derivatives from the aspects of structure-activity relationship and anti-tumor mechanism to provide reference for the research and utilization of shikonin in the future.

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重大新药创制科技重大专项（2018ZX09201-010）