目的 优选养阴清肺汤加味提取工艺。方法 采用HPLC法同时测定毛蕊花糖苷、丹皮酚、绿原酸、甘草酸，以层次分析法（AHP）计算权重系数，多指标综合评分结合Box-Behnken设计-响应面法考察乙醇体积分数、提取时间、提取次数对养阴清肺汤加味提取工艺的影响，优选醇提工艺。结果 最佳提取工艺为采用69%乙醇，提取68 min，提取1次。结论 优选的提取工艺简单可行，成分提取效率高，为养阴清肺汤加味提取工艺提供参考。

Objective To optimize the extraction process of Modified Yangyin Qingfei Decoction (MYQD). Methods The effects of ethanol concentration, extraction time and extraction times on the optimization of extraction process of MYQD were investigated by multiple indicators comprehensive scoring and Box-Behnken response surface methodology. The content of verbascoside, chlorogenic acid, paeonol, and glycyrrhizic acid was simultaneously determined by HPLC, and the method of analytic hierarchy process was used to calculate the weight coefficient. Results The optimum extraction process was as follow:using 69% ethanol for once extraction for 68 min. Conclusion The optimum extraction process is simple and feasible, and the extraction efficiency of components is high, which can provide reference for the extraction process of MYQD.

R284.2

国家自然科学基金面上项目（81373687）；国家自然科学基金面上项目（81874490）；第四批全国中医（临床、基础）优秀人才研修项目（国中医药人教发[2017]24号）；辽宁省“百千万人才工程”人选资助项目（辽人社[2018]47号）；沈阳市中青年科技创新人才支持项目（RC180246）