目的 以推进"无水服药"新理念对天地震颤速溶散进行设计及评价。方法 自拟处方设计制备天地震颤速溶散，并以自制细粉为对比，以口感、粉体学性质和溶化性进行天地震颤速溶散的评价。结果 制备的天地震颤速溶散口感良好，口腔滞留时间短，粉体学性质优良。结论 速溶散是一种优良的新型剂型，以天地震颤速溶散为例，为推进"无水服药"新理念提供了新的剂型与评价参考。

Objective To design and evaluate Tiandi Zhenchan Instant Powder (TZIP) by promoting the new concept of "taking drugs without water". Methods The self-designed formula was used to prepare TZIP. Compared with self-made fine powder, TZIP was evaluated by using taste evaluation, powder properties and solubility evaluation as indicators. Results The powder had the properties of good taste, short oral retention time and good powder properties. Conclusion Instant powder is an excellent new dosage form. In this paper, TZIP is taken as an example to provide a new dosage form and evaluation reference for promoting the new concept of "taking drugs without water".

R283.6

国家自然科学基金面上项目：基于表面修饰的中药粉体亲水性调控工艺设计与系统评价——以青黛为例（81773918）；四川省科技厅重点研发计划：帕金森综合症中药创新新药——天地镇颤颗粒的候选药物研究（2017SZ0093）