目的 观察宁泌泰胶囊联合地红霉素肠溶片治疗精液解脲脲原体（Uu）培养阳性精液不液化症的临床疗效。方法 将精液Uu培养阳性的精液不液化症患者120例按2：1比例随机分为治疗组80例，对照组40例，连续用药2周为1个疗程，观察2个疗程。治疗组口服宁泌泰胶囊4粒/次，3次/d，同时口服地红霉素肠溶片0.5 g/次，1次/d，均饭后服用，对照组仅口服地红霉素肠溶片。主要观察Uu转阴率、精液液化时间，并观察不良反应。结果 治疗2周、4周后治疗组和对照组Uu转阴率分别为72.5%、95.0%和55.0%、92.5%，治疗2周后治疗组转阴率明显高于对照组（P<0.05），总的转阴率两组比较无统计学意义（P>0.05）。治疗组和对照组精液液化时间治疗前分别为（76.19±14.13）、（77.08±13.34）min，治疗2周后分别为（58.64±13.15）、（67.12±12.52）min，治疗4周后分别为（48.64±12.38）、（56.12±12.86）min，两组治疗前后精液液化时间比较差异显著（P<0.05），组间比较治疗组明显优于对照组（P<0.01）。结论 宁泌泰胶囊联合地红霉素肠溶片能部分缩短Uu转阴的时间，明显缩短精液液化时间，对Uu阳性精液不液化症有明显的临床疗效。

Objective To investigate the clinical effect of Ningmitai Capsule combined with Dirithromycin Enteric Tablets in the treatment of positive semen nonliquefaction in the culture of Ureaplasma urealyticum (Uu). Methods A total of 120 cases of semen liquefaction patients with positive semen Uu culture were randomly divided into treatment group with 80 cases and control group with 40 cases, which were continuous administrated for two weeks for a period of treatment and observated for two courses of treatment. In the treatment group, four Ningmitai Capsules were taken orally per time, three times per day, and 0.5 g Dirithromycin Enteric Tablets were taken orally per time, once per day, after meals, while the control group only took the Dirithromycin Enteric Tablets orally. Uu negative conversion rate and semen liquefaction time (min) were observed, and adverse reactions were also observed. Results The Uu negative conversion rate in the treatment group and control group after 2 weeks, 4 weeks was 72.5%, 95.0% and 55%, 92.5%, respectively, the negative conversion rate of treatment group was obviously higher than that of control group after 2 weeks treatment (P < 0.05), and there has no statistical significance in the total negative conversion rate of two groups (P > 0.05). The semen liquefaction time before treatment in the treatment group and control group respectively was (76.19 ±14.13) min and (77.08 ±13.34) min, which was (58.64 ±13.15) min and (67.12 ±12.52) min two weeks after treatment, (48.64 ±12.38) min and (56.12 ±12.86) min 4 weeks after treatment were, semen liquefaction time of the two groups before and after treatment was significant different (P < 0.05), and the treatment group was better than control group (P < 0.01). Conclusion Ningmitai Capsule combined with Dirithromycin Enteric Tablets can partly shorten the Uu negative conversion time, obviously shorten the semen liquefaction time, and has obvious clinical efficacy for Uu positive semen nonliquefaction disease.

R287.3