目的 研究苦木Picrasma quassioidies茎的生物碱类化学成分。方法 采用CG161M、硅胶、ODS、Sephadex LH-20等多种柱色谱分离技术进行分离纯化，并根据理化性质和波谱数据鉴定化合物结构。结果 从苦木茎的85%乙醇提取液中分离得到16个生物碱类化合物，其中包括12个β-咔巴啉型生物碱，分别鉴定为1-（1-羟基）-乙基-6-羟基-β-咔巴啉（1）、6-hydroxy-β-carboline-1-carboxylic（2）、β-carboline-1-carboxylic acid（3）、β-carboline-1-propanoic acid（4）、3-hydroxy-β-carboline（5）、1-acetyl-β-carboline（6）、1-乙氧甲酰基-β-咔巴啉（7）、1-（9H-β-carbolin-1-yl）-ethanol（8）、picrasidine X（9）、1-羟甲基-β-咔巴啉（10）、9H-pyrido[3，4-b]indole（11）、6-hydroxy-2-methyl-9H-β-carbolin-2-ium（12）；4个铁屎米酮型生物碱，分别鉴定为4，5-dimethoxycanthin-6-one（13）、3-methylcanthin-5，6-dione（14）、5-hydroxy-4-methoxylcanthin-6-one（15）、picrasidine O（16）。结论 化合物1为1个新的β-咔巴啉型生物碱，命名为苦木碱Z；化合物12为新天然产物。

Objective To study the alkaloids from the stems of Picrasma quassioidies. Methods The isolation and purification were carried out by column chromatography on CG161M, silica gel, ODS, and Sephadex LH-20. The structures were elucidated on the basis of physicochemical properties and spectroscopic analysis. Results A total of 16 alkaloids were isolated and identified from 85% ethanol aqueous extract of the stems of P. quassioidies. It included 12 β-carboline alkaloids including 1-(1-hydroxy)-ethyl-6-hydroxy-β-carboline (1), 6-hydroxy-β-carboline-1-carboxylic acid (2), β-carboline-1-carboxylic acid (3), β-carboline-1-propanoic acid (4), 3-hydroxy-β-carboline (5), 1-acetyl-β-carboline (6), 1-ethoxycarbonyl-β-carboline (7), 1-(9H-β-carbolin-1-yl)-ethanol (8), picrasidine X (9), 1-hydroxymethyl-β-carboline (10), 9H-pyrido[3,4-b] indole (11), 6-hydroxy-2-methyl-9H-β-carbolin-2-ium (12); and four cantin-6-one alkaloids, including 4,5-dimethoxycanthin-6-one (13), 3-methylcanthin-5,6-dione (14), 5-hydroxy-4-methoxylcanthin-6-one (15), and picrasidine O (16). Conclusion Compound 1 is a new β-carboline alkaloid named picrasidine Z, and compound 12 is a new natural product.

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