目的 研究巴西甘菊花Achyrocline satureioides的化学成分。方法 应用多种色谱技术对巴西甘菊花进行分离纯化，并通过光谱方法鉴定化合物的结构。结果 从巴西甘菊花醋酸乙酯部位中分离得到21个化合物，分别鉴定为香树脂醇（1）、豆甾-4，6，8，22-四烯-3-酮（2）、豆甾-4-烯-3，6-二酮（3）、clovandiol（4）、caryolane-1，9β-diol（5）、lepidissipyrone（6）、5，7-二羟基-3，6-二甲氧基黄酮（7）、槲皮素-7-O-β-D-葡萄糖苷（8）、5，7-二羟基二氢黄酮（9）、二氢槲皮素（10）、槲皮素-4'-O-β-D-葡萄吡喃糖苷（11）、helichrysetin（12）、3-[5，7-dihydroxy-2，2-dimethyl-8-（2-（S）-methyl-butanoyl）-2H-chromen-6-yl-methyl]-6-ethyl-4-hydroxy-5-methyl-pyran-2-one（13）、槲皮素（14）、原儿茶酸（15）、（+）-（3R）-3-hydroxyl-4，4-dimethyl-4-butyrolactone（16）、（4S，5R）-5-（4'-methyl-3'-pentenyl）-4-hydroxy-5-methyldihydrofuran-2-one（17）、芫花素（18）、槲皮素-3-甲醚（19）、高良姜素（20）、新野樱苷（21）。结论 化合物1、4、5、16、17、21为首次从该属植物中分离得到，化合物1~12、16~18、21为首次从该植物中分离得到。

Objective To study the chemical constituents from Achyrocline satureioides. Methods Chemical constituents from A. satureioides were separated and purified by a variety of chromatographic techniques, and their structures were identified by various spectroscopic methods. Results Twenty-one compounds were isolated from ethyl acetate fraction of the plant, which were α-amyrin (1), ergosta-4,6,8,22-tetraene-3-one (2), (R)-24-ethylcholest-4-en-3,6-dione (3), clovandiol (4), caryolane-1,9β-diol (5), lepidissipyrone (6), 5,7-dihydroxy-3,6-dimethoxyflavone (7), quercetin-7-O-β-D-glucoside (8), pinocembrin (9), (2R,3R)-taxifolin (10), quercetin-4'-O-β-D-glucoside (11), helichrysetin (12), 3-[5,7-dihydroxy-2,2-dimethyl-8-(2-(S)-methyl-butanoyl)-2H-chromen-6-yl-methyl]-6-ethyl-4-hydroxy-5-methyl-pyran-2-one (13), quercetin (14), protocatechuic acid (15), (+)-(3R)-3-hydroxyl-4,4-dimethyl-4-butyrolactone (16), (4S,5R)-5-(4'-methyl-3'-pentenyl)-4-hydroxy-5-methyldihydrofuran-2-one (17), genkwanin (18), quercetin-3-methyl ether (19), galangin (20), and neosakuranin (21). Conclusion Compounds 1, 4, 5, 16, 17, and 21 are obtained from the genus for the first time, and compounds 1-12, 16-18, and 21 are obtained from the plant for the first time.

R284.1

中央本级重大增减支项目（2060302）；江西中医药大学院士工作站项目（YSGZZ201801）；江西中医药大学一流学科项目（JXSYLXK-ZHYAO144）