目的 研究少数民族药物红葱Eleutherine americana的化学成分。方法 采用硅胶、半制备高效液相分离、TLC检识等方法进行分离纯化，通过NMR、MS等波谱数据鉴定化合物结构。结果 从红葱中分离出5个化合物，分别鉴定为红葱醌A（1）、elecanacin（2）、3-[2-（乙酰氧基）丙基]-2-羟基-8-甲氧基-1，4-萘醌（3）、2-乙酰基-1，8-二甲氧基-3-甲基萘（4）、二羟基艾榴醇（5）。结论 化合物1为1个新化合物，化合物1~5均有不同程度抑制金黄色葡萄球菌和大肠杆菌生长的作用，其中化合物5对2种菌的最小抑菌浓度（MIC）分别为0.30、0.06 μg/mL。

Objective To study the chemical constituents from the ethnic medicines of Eleutherine americana. Methods Compounds were separated by silica gel and semi-preparative HPLC, detected by TLC, and identified by their NMR and MS data. Results Five compounds were isolated from E. americana. They were ameriquinone A (1), elecanacin (2), 3-[2-(acetyloxy) propyl]-2-hydroxy-8-methoxy-1,4-naphthoquinone (3), 2-acetyl-1,8-di-methoxy-3-methylnaphthalene (4), and dihydroeleutherinol (5). Conclusion Compound 1 is a new compound. Compounds 1-5 have different degrees of inhibitory effect on the growth of Staphylococcus aureus and Escherichia coli. The MIC values of compound 5 against two strains were 0.30 μg/mL and 0.06 μg/mL, respectively.

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海南省重点研发计划（ZDYF2017127）；北京城市学院2018年度实培计划项目经费资助