目的 通过响应面法优化延胡索产地鲜切加工工艺，得到延胡索产地鲜切加工的最佳工艺。方法 以切片厚度、热风干燥温度、装载量为考察因素，以总生物碱含量、浸出物含量、干燥效率为考察指标，通过主成分分析法得到各指标的权重系数，计算综合评分，对考察因素进行单因素分析，得到初步优化范围，最后以响应面优化法进行优化，得到最后工艺优化参数。结果 确定最佳产地鲜切加工工艺：切片厚度为4 mm，干燥装载量为7 kg/m²，干燥温度为85℃，干燥总时间为（279.0±1.1）min，综合评分为0.860 6±0.010 0，此时延胡索总生物碱质量分数为（6.274±0.030）mg/g；浸出物质量分数为（17.86±0.22）%；干燥效率为（25.09±0.00）g/（m²·min）。结论 建立的干燥工艺能够较好地保留延胡索中生物碱成分和浸出物，保持较高的干燥效率，在保证较高的质量同时，降低企业能耗，可为延胡索饮片的生产加工提供可靠的理论依据。

Objective To optimize the fresh-cutting process of Corydalis Rhizoma by response surface methodology, and obtain the best technology for fresh-cut processing of Corydalis Rhizoma. Methods The slice thickness, the hot air drying temperature and the loading amount were taken as the investigation factors. The total alkaloid content, the extract content and the drying efficiency were taken as the indicators. The weight coefficient of each index was obtained by principal component analysis method, and the comprehensive score was calculated. Single factor analysis was performed on the investigation factors to obtain the initial optimization range, and the response surface optimization method was used to optimize the final process optimization parameters. Results The best production conditions for fresh-cut processing were determined as slice thickness of 4 mm, dry load of 7 kg/m², drying temperature of 85℃, total drying time of (279.0 ±1.1) min, and comprehensive score of (0.860 6 ±0.010 0). At this time, the total alkaloid content of Corydalis Rhizoma was (6.274 ±0.030) mg/g, the content of the leachate was (17.86 ±0.22)%, and the drying efficiency was (25.09 ±0.00) g/(m²·min). Conclusion The established drying process can better preserve the content of alkaloids and extracts in Corydalis Rhizoma, maintain high drying efficiency, ensure high quality and reduce energy consumption of enterprises, and provide a reliable theoretical basis for the production and processing of Corydalis Rhizoma pieces.

国家中药标准化项目（ZYBZH-H-ZY-45）；中医药行业科研专项“中药饮片质量保障系统研究（一）”（201507002）；浙江中医药大学国家自然科学基金预研专项（2018ZG34）；中华中医药学会青年人才托举工程项目中华中医药学会青年人才托举工程项目（QNRC2-C12）