目的 观察百蕊颗粒联合氧氟沙星滴耳液治疗儿童急性化脓性中耳炎的疗效。方法 选取本院186例儿童急性中耳炎患者，随机分为治疗组94例（百蕊颗粒+氧氟沙星滴耳液）和对照组92例（氧氟沙星滴耳液），对照组采用0.3%氧氟沙星滴耳液滴耳，每日2~3次，每次6~10滴，滴耳后进行约10 min耳浴；治疗组除采用0.3%氧氟沙星滴耳液外，还口服百蕊颗粒，3次/d，每次5 g/次；两组均治疗7~10 d，观察疗效及不良反应情况。结果 总有效率治疗组为94.68%，对照组为82.61%，两组疗效差异显著（P<0.05）；治疗组患者症状和体征改善程度明显好于对照组（P<0.05），两组不良反应发生情况差异不显著。结论 单用氧氟沙星滴耳液可有效治愈儿童急性化脓性中耳炎，联用百蕊颗粒后有效率显著提升，症状和体征显著改善，且安全性好，值得推广使用。

Objective To study the curative effect of ofloxacin ear drops combined with Bairui Granules on acute suppurative otitis media in children. Methods A total of 186 pediatric patients with acute suppurative otitis media treated in Qinhuangdao City Chinese Medicine Hospital were divided into the treatment group and control group according to the random number table method. In the treatment group, 94 patient were treated with 0.3% ofloxacin ear drops combined with Bairui Granules. In the control group, children in the 92 cases only received ofloxacin ear drops (2-3 times a day, 6-10 drops each time; After ear dropping, taking 10 min ear bath). Each group was treated 7-10 d. The curative effect and adverse reactions were observed. Results The total effective rate of the treatment group was 94.68% and the control group was 82.61%, there was a significant difference between the two groups. (P <0.05). The improvement in symptom and physical scores of the treatment group was significantly better than that of the control group (P <0.05). There was no significant difference in the incidence of adverse reactions between two groups. Conclusion The ofloxacin ear drops can efficiently improve clinical symptoms of the patients with acute suppurative otitis media, and Bairui Granules have antipyretic and antiphlogistic effect. The combination of the two drugs had significant curative effect on acute suppurative otitis media in children with low adverse reactions incidence, so we conclude that it is worthy to be promoted.