木脂素是由2分子及以上苯丙素衍生物聚合而成的一类天然化合物，多存在于植物的木质部和树脂中，具有抗肿瘤、抗人类免疫缺陷病毒（HIV）、降血糖、抗氧化、保护心血管和肝脏等广泛的生物活性。但该类化合物溶解度差，导致其临床应用受限，因此，研究者多采用化学方法对其结构进行改造与修饰。对近年来几种代表性木脂素类成分牛蒡苷元、鬼臼毒素、五味子木脂素、厚朴酚、和厚朴酚等的化学结构修饰及衍生物的药理活性研究进行综述，以期为木脂素类化合物的深入研究和开发利用提供依据。

Lignans which are polymerized by two or more phenylpropanoids derivatives were mostly found in the xylem and resin of plants. Modern pharmacological studies have shown that lignans have extensive biological activities, such as anti-tumor, anti-HIV, antidiabetics, anti-oxidant, cardiovascular and liver protections and so on. However, owing to the poor solubility of structures, its clinical application is still limited. Therefore, chemical modification methods are usually used by domestic and overseas researchers in order to improve their solubility. In this paper, a series of typical lignans such as arctigenin, podophyllotoxin, schisandrin, magnolol, and honokiol were taken as examples to summarize their structural modification methods and different biological activities, aiming to provide scientific basis for further exploitation and studies of lignans.

教育部重点研发计划项目（2016YFC0500300）；吉林省科技发展计划项目（20180520060JH）；吉林省教育厅"十三五"项目（JJKH20170321KJ）；吉林省科技厅重点科技攻关项目（20170204017YY）