目的 研究山药Dioscorea opposita化学成分。方法 采用硅胶、Sephadex LH-20、反相ODS等柱色谱方法对化合物进行分离纯化，运用核磁共振波谱等方法鉴定化合物的结构。结果 从山药根茎95%乙醇提取物中分离纯化得到14个化合物，包括8个二苯基庚烷类化合物（1～8）和6个含氮化合物（9～14），分别鉴定为5-ethoxy-1,7-diphenylheptan-3-one（1）、5-hydroxy-1,7-bis(4-hydroxyphenyl)-heptan-3-one（2）、1,7-diphenyl-4-hepten-3-one（3）、1,7-bis(4-hydroxyphenyl)-4-hepten-3-one（4）、hannokinol（5）、1-(4-hydroxy-3-methoxyphenyl)-7-(4-hydroxyphen-yl)-3,5-heptanediol（6）、1,7-bis(4-hydroxy-3-methoxyphenyl)- 3,5-heptanediol（7）、1,7-bis(4-hydroxyphenyl)-1,5-epoxy-3-hydroxyheptane（8）、trans-N-coumaroyltyramine（9）、trans-N-feruloyltyramine（10）、cis-N-coumaroyltyramine（11）、trans-N-cinnamoyltyramine（12）、pyrrolezanthine-6-ethyl ether（13）、divaricataester A（14）。结论 化合物1是新的天然产物，命名为山药庚酮A，化合物3、4、10、12～14为首次从薯蓣科植物中分离得到，化合物2、6、8为首次从山药中分离得到。

Objective To study the chemical constituents of Dioscorea opposita. Methods The constituents were isolated and purified by silica gel, Sephadex LH-20, and ODS column chromatography. Their structures were elucidated by NMR spectra comparison with reference data. Results Fourteen compounds were isolated from 95% ethanol extract of D. opposite. All of them included eight diarylheptanoids (1-8) and six nitrogen compounds (9-14). They were elucidated by spectroscopic data as 5-ethoxy-1,7-diphenylheptan-3-one (1), 5-hydroxy-1,7-bis(4-hydroxyphenyl)-heptan-3-one (2), 1,7-diphenyl-4-hepten-3-one (3), 1,7-bis (4-hydroxyphenyl)-4-hepten-3-one (4), hannokinol (5), 1-(4-hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)-3,5-heptanediol (6), 1,7-bis (4-hydroxy-3-methoxyphenyl)-3,5-heptanediol (7), 1,7-bis(4-hydroxyphenyl)-1,5-epoxy-3-hydroxyheptane (8), trans-N- coumaroyltyramine (9), trans-N-feruloyltyramine (10), cis-N-coumaroyltyramine (11), trans-N-cinnamoyltyramine (12), pyrrolezanthine-6-ethyl ether (13), divaricataester A (14). Conclusion Compounds 1 is a new natural product, named as dioscoheptone A. Compounds 3, 4, 10, 12, 13, and 14 are isolated from the family of dioscoreaceae for the first time. Compounds 2, 6, and 8 are isolated from D. opposita for the first time.

国家中药标准化项目（ZYBZH-C-JL-24）