目的 比较不同干燥方法对干姜药材中6种活性成分的影响，探讨干燥过程中干姜成分的动态变化和水分动力学变化。方法 采用HPLC同时测定干姜中的多元功效成分，以6-姜酚、8-姜酚、10-姜酚、6-姜烯酚、α-姜黄烯、（E）-β-金合欢烯为指标，对不同干燥方法所得干姜进行综合评价；利用Weibull函数模拟干姜干燥过程中水分的动态变化结合成分动态变化，探讨干姜干燥过程的原理。结果 12种干燥方法对干姜中多元功效成分有一定影响，干燥过程各成分呈波动变化，Weibull函数模拟干姜干燥过程的r²均大于0.990。以控温鼓风60℃干燥所得干姜较优；含水量范围6%～15%为干姜加工的适宜水分；干姜干燥过程中6-姜酚、8-姜酚、10-姜酚和6-姜烯酚与含水量呈显著的负相关关系。结论 Weibull分布函数能够较好的模拟干姜干燥过程的水分变化，对干姜干燥过程的预测、调控具有重要意义，同时为使用现代干燥技术干燥干姜药材提供了技术依据。

Objective To compare the effects of different drying methods on six bioactive constituents of Zingiberis Rhizoma (ZR), and explore the dynamic changes of bioactive constituents and water content during the drying process. Methods The multiple components in ZR were simultaneously measured by HPLC, and 6-gingerol, 8-gingerol, 10-gingerol, 6-shogaol, α-curcumene, (E)-β-farnesene were used as indexes to evaluate ZR obtained from different drying methods. The Weibull function was used to simulate the dynamic change of water content, which was combined with the dynamic changes of components during the drying process of ZR to explore the principle of drying process. Results A total of 12 kinds of drying methods had a certain effect on the multiple components of ZR, and the components presented the fluctuation change in the drying process. The coefficient of correlation of Weibull functional simulation of ZR drying process was greater than 0.990. Conclusion ZR obtained by drying at 60℃ was better. Water content range of 6%-15% was suitable for processing ZR. 6-gingerol, 8-gingerol, 10-gingerol, and 6-shogaol were significantly negatively correlated with the moisture content of ZR. The Weibull distribution model could well simulate the fluctuation change of water content in the drying process, and it was of great significance for the prediction and quality control of ZR during drying process, which could also provide a technical basis for the use of modern drying technology to dry ZR at the same time.

国家中药标准化项目“新生化颗粒标准化建设”（ZYBZH-C-JS-34）；国家现代农业产业技术体系建设专项资金资助（CARS-21）