目的 研究青龙衣醇提取物正丁醇部位的化学成分。方法 采用常规硅胶柱、反相ODS及半制备高效液相色谱等进行分离制备，利用各种谱学技术鉴定化合物的结构。结果 从青龙衣正丁醇萃取部位分离得到了8个化合物，分别鉴定为4-羟基-4-（3'-羟基苯酚）丁酸-4-O-β-D-吡喃葡萄糖苷乙酯（1）、4-羟基-4-（3'-羟基苯酚）丁酸-4-O-β-D-吡喃葡萄糖苷甲酯（2）、1，4，8-三羟基萘-1-O-β-D-吡喃葡萄糖苷（3）、1，4，8-三羟基-3-萘甲酸乙酯-1-O-β-D-吡喃葡萄糖苷（4）、（4S）-4，5，8-三羟基-α-四氢萘酮-4-O-β-D-吡喃葡萄糖苷（5）、（4S）-4，5，8-三羟基-α-四氢萘酮-5-O-β-D-[6'-O-（3″，4″，5″-三羟基苯甲酰基）]吡喃葡萄糖苷（6）、（4S）-4-羟基-α-四氢萘酮-4-O-β-D-（6'-O-4″-羟基苯甲酰基）吡喃葡萄糖苷（7）、（4S）-4，5-二羟基-α-四氢萘酮-4-O-β-D-（6'-O-4″-羟基苯甲酰基）吡喃葡萄糖苷（8）。结论 化合物1、2为新化合物，分别命名为胡桃酚苷P和胡桃酚苷Q。

Objective To study the chemical constituents of the n-butanol part which extracted from green walnut husks of Juglans mandshurica with antitumor activity. Methods The chemical constituents from 95% EtOH extract of green walnut husks of J. mandshurica at room temperature were isolated and prepared by silica gel column, reversed-phase ODS, and pre-HPLC after n-butanol extraction, and their structures were elucidated by a variety of spectral and spectroscopic techniques. Results Eight compounds were isolated and identified as 4-hydroxy-4-(3'-hydroxyphenol) butanoic acid-4-O-β-D-glucopyranoside ethyl ester (1), 4-hydroxy-4-(3'-hydroxyphenyl) butyric acid-4-O-β-D-glucopyranoside methyl ester (2), 1,4,8-trihydroxynaphthalene-1-O-β-D-glucopyranoside (3), 1,4,8-trihydroxy-3-naphthoic acid ethyl ester-1-O-β-D-glucopyranoside (4), (4S)-4,5,8-trihydroxy-α-tetralone-4-O-β-D-glucopyranoside (5), (4S)-4,5,8-trihydroxy-α-tetralone-5-O-β-D-[6'-O-(3″,4″,5″-trihydroxybenzoyl)] glucopyranoside (6), (4S)-4-hydroxy-α-tetralone-4-O-β-D-(6'-O-4″-hydroxylbenzoyl)-glucopyranoside (7), and (4S)-4,5-dihydroxy-α-tetralone-4-O-β-D-(6'-O-4″-hydroxylbenzoyl)-glucopyranoside (8). Conclusion Compound 1 named juglanoside P and compound 2 namded juglanoside Q are both new compounds.

国家自然科学基金资助项目（81202890）；中国博士后特别资助项目（2014T70374）；中国博士后面上资助项目（一等，2013M530164）；黑龙江省博士后科研启动金资助项目（LBH-Q16207）；哈尔滨市青年科技创新人才项目（2013RFQXJ052）；黑龙江中医药大学博士创新基金项目（B201103）；黑龙江中医药大学优秀创新人才支持项目（051248）