山豆根被誉为治疗咽喉肿痛的第一要药，临床应用广泛。因山豆根毒效并存，临床常因不合理应用导致一系列的安全问题，结合近30年文献报道，剖析山豆根产生毒性反应的根本原因，并从化学成分的角度探讨其发挥药效及产生毒性的实质，对如何促进山豆根临床合理应用提出探索性的思考。

Sophorae Tonkinensis Radix et Rhizoma is known as the important drug for treating sore throat and is widely used in clinic. Because of the coexisting of its efficacy and poison, Sophorae Tonkinensis Radix et Rhizoma often leads to a series of safety problems in the clinical application process. In this study, we attempt to analyze the ultimate cause of the toxicity of Sophorae Tonkinensis Radix et Rhizoma by reviewing nearly 20 years of literature, discuss the substance of its efficacy/toxicity from the point of view of chemical composition, and put forward exploratory thinking on its clinical rational application.

国家自然科学基金资助项目（81673618，81403152）；教育部高等学校博士学科点专项科研基金（20120013130002，20130013120001）