目的 采用热熔挤出技术制备姜黄素固体分散体，以提高姜黄素的溶解度和溶出度。方法 以姜黄素为模型药物，丙烯酸树脂Eudragit E PO（EPO）为载体，溶解度参数法评价药物与载体的相容性。以姜黄素的含量、结晶度和溶出度为评价指标，单因素实验筛选热熔挤出过程中的机筒温度、螺杆转速和冷却速率，优化制备工艺，并与溶剂法和熔融法比较。结合差示扫描量热法、X射线衍射法、傅里叶变换红外光谱法、饱和溶解度测定和体外溶出度试验等对热熔挤出最佳工艺制备的固体分散体进行表征与评价。结果 最佳制备工艺：螺杆转速为100 r/min，机筒温度为130～160℃，冷却方式为液氮冷却。此条件下制备的姜黄素固体分散体，药物以无定形态分散在载体中，药物与载体间形成较强的相互作用。结论 热熔挤出技术可制备热敏性姜黄素分散体，为采用热熔挤出技术制备热敏性药物固体分散体的研究提供了一定的实验参考。

Objective Hot-melt extrusion technique was applied to prepare curcumin solid dispersions, which can improve the solubility and dissolution of curcumin. Methods Using curcumin as a model drug and Eudragit E PO (EPO) as a carrier, the solubility parameter method was used to evaluate the miscibilty between the drug and the carrier. Taking the content, crystallinity, and dissolution of curcumin as evaluation indicators, the single-factor test was used to select the barrel temperature, screw speed, and cooling rate in the hot-melt extrusion process. The preparation process was optimized and compared with the solvent method and the fusion method. By means of differential scanning calorimetry, X-ray diffraction, Fourier transform infrared spectroscopy, saturated solubility measurement and in vitro dissolution test, the solid dispersions prepared by the best hot-melt extrusion process were characterized and evaluated. Results The best preparation process were as follow:screw speed 100 r/min, barrel temperature 130-160℃, and cooling mode of liquid nitrogen cooling. Under such condition, the drug was dispersed in the carrier in an amorphous state, and a strong molecular interaction occurred between the drugs and the carriers. Conclusion Hot-melt extrusion technique can be applied for the preparation of heat-sensitive curcumin dispersions, which provides a certain experimental reference for the preparation of heat-sensitive drug solid dispersions by hot-melt extrusion.

国家自然科学基金资助项目（30801552，81274095）；江苏省中药资源产业化过程协同创新中心第三批立项资助重点项目（012092002006-10）；第55批博士后课题（021062001001）